CIN4/YMR138W Protein Information

Standard Name	Cin4p 1, 2
Systematic Name	Ymr138wp
Alias	Gtp1p , Ugx1p
ORF Classification	Verified
Description	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog (1, 3, 4, 5)
Name Description	Chromosome INstability 1

Experimental Data
Molecules/cell	468 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	191
Molecular Weight (Da)	22,066
Isoelectric Point (pI)	5.83

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cin4p (InterPro)
Physical Interactions	There are 15 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001279CF \| P39110 MIPS: YMR138W NCBI: 443969 \| 45270708 \| 556462 \| 606436 \| 6323787 \| 729139 \| NP_013858.1 GenBank/EMBL/DDBJ: DAA10035.1 \| AY558409 \| L36669 \| X77086 \| Z47071

Amino Acid Sequence (or in FASTA format)
1 MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT 51 VGFQIHSLMI KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM 101 RFDETLQELK ELINRDENRI GYECAVIVVL NKIDLVEDKS ELHRRCLLVE 151 SELKCLFKPD IRIELVKCSG VTGEGIDNLR DRLVESCHFT Q*

Amino Acid Sequence (or in FASTA format)

       1  MGLLSIIRKQ KLRDKEIRCL ILGLDNSGKS TIVNKLLPKD EQNNDGIMPT
      51  VGFQIHSLMI KDVTISLWDI GGQRTLRPFW DNYFDKTQAM IWCIDVSLSM
     101  RFDETLQELK ELINRDENRI GYECAVIVVL NKIDLVEDKS ELHRRCLLVE
     151  SELKCLFKPD IRIELVKCSG VTGEGIDNLR DRLVESCHFT Q*

external links for Cin4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Cin4p

1)	Stearns T, et al. (1990) Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics 124(2):251-62
2)	Stearns, T. and Botstein, D. (1989) Personal Communication, Mortimer Map Edition 10
3)	Hoyt MA, et al. (1990) Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Mol Cell Biol 10(1):223-34
4)	Bhamidipati A, et al. (2000) ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. J Cell Biol 149(5):1087-96
5)	Veltel S, et al. (2008) The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nat Struct Mol Biol 15(4):373-80
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41