MED11/YMR112C Protein Information Help

Standard Name Med11p 1
Systematic Name Ymr112cp
ORF Classification Verified
Description Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein (1, 2, 3)
Name Description MEDiator complex 1
Experimental Data
Molecules/cell 396 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 131
Molecular Weight (Da) 15,169
Isoelectric Point (pI) 5.15

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Med11p (InterPro)
Physical Interactions There are 81 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0002374963 | Q99278
MIPS: YMR112C
NCBI: 1326012 | 2497153 | 330689678 | 330689680 | 330689682 | 330689684 | 330689686 | 330689688 | 330689690 | 330689692 | 330689694 | 330689696 | 330689698 | 330689700 | 345100884 | 345100891 | 345100898 | 363548432 | 410563049 | 410563056 | 410563145 | 45270702 | 459358306 | 6323759 | 817870 | NP_013830.1 | NM_001182612.1
GenBank/EMBL/DDBJ: DAA10009.1 | AY558406 | Z49702
Amino Acid Sequence (or in FASTA format)
 
       1  MQVLNTKSET KQENETMQPP YIQERLKSLN DIETQLCSML QEASQVTFIF
      51  GELKRGNESV KPQFENHVKQ FYERLDKSTT QLRKEIQLLD ENVGTRLLPI
     101  NVNKKALGQD TEKMEEQLDL LSAILDPSKS K*

external links for Med11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome


DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Med11p
1) Gustafsson CM, et al.  (1998) Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae. J Biol Chem 273(47):30851-4
2) Kornberg RD  (2005) Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 30(5):235-9
3) Takagi Y, et al.  (2006) Head module control of mediator interactions. Mol Cell 23(3):355-64
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41