HFD1/YMR110C Protein Information

Standard Name	Hfd1p 1
Systematic Name	Ymr110cp
ORF Classification	Verified
Description	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder (1, 2)
Name Description	Homolog of Fatty aldehyde Dehydrogenase 1

Experimental Data
Molecules/cell	2930 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	532
Molecular Weight (Da)	59,978
Isoelectric Point (pI)	6.73

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hfd1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F957 \| Q04458 MIPS: YMR110C NCBI: 2494079 \| 6323757 \| 817868 \| NP_013828.1 GenBank/EMBL/DDBJ: DAA10007.1 \| Z49702
External Classifications	EC: 1.2.1.- [Oxidoreductases, Acting on the aldehyde or oxo group of donors, With NAD(+) or NADP(+) as acceptor]

Amino Acid Sequence (or in FASTA format)
1 MSNDGSKILN YTPVSKIDEI VEISRNFFFE KQLKLSHENN PRKKDLEFRQ 51 LQLKKLYYAV KDHEEELIDA MYKDFHRNKI ESVLNETTKL MNDILHLIEI 101 LPKLIKPRRV SDSSPPFMFG KTIVEKISRG SVLIIAPFNF PLLLAFAPLA 151 AALAAGNTIV LKPSELTPHT AVVMENLLTT AGFPDGLIQV VQGAIDETTR 201 LLDCGKFDLI FYTGSPRVGS IVAEKAAKSL TPCVLELGGK SPTFITENFK 251 ASNIKIALKR IFFGAFGNSG QICVSPDYLL VHKSIYPKVI KECESVLNEF 301 YPSFDEQTDF TRMIHEPAYK KAVASINSTN GSKIVPSKIS INSDTEDLCL 351 VPPTIVYNIG WDDPLMKQEN FAPVLPIIEY EDLDETINKI IEEHDTPLVQ 401 YIFSDSQTEI NRILTRLRSG DCVVGDTVIH VGITDAPFGG IGTSGYGNYG 451 GYYGFNTFSH ERTIFKQPYW NDFTLFMRYP PNSAQKEKLV RFAMERKPWF 501 DRNGNNKWGL RQYFSLSAAV ILISTIYAHC SS*

Amino Acid Sequence (or in FASTA format)

       1  MSNDGSKILN YTPVSKIDEI VEISRNFFFE KQLKLSHENN PRKKDLEFRQ
      51  LQLKKLYYAV KDHEEELIDA MYKDFHRNKI ESVLNETTKL MNDILHLIEI
     101  LPKLIKPRRV SDSSPPFMFG KTIVEKISRG SVLIIAPFNF PLLLAFAPLA
     151  AALAAGNTIV LKPSELTPHT AVVMENLLTT AGFPDGLIQV VQGAIDETTR
     201  LLDCGKFDLI FYTGSPRVGS IVAEKAAKSL TPCVLELGGK SPTFITENFK
     251  ASNIKIALKR IFFGAFGNSG QICVSPDYLL VHKSIYPKVI KECESVLNEF
     301  YPSFDEQTDF TRMIHEPAYK KAVASINSTN GSKIVPSKIS INSDTEDLCL
     351  VPPTIVYNIG WDDPLMKQEN FAPVLPIIEY EDLDETINKI IEEHDTPLVQ
     401  YIFSDSQTEI NRILTRLRSG DCVVGDTVIH VGITDAPFGG IGTSGYGNYG
     451  GYYGFNTFSH ERTIFKQPYW NDFTLFMRYP PNSAQKEKLV RFAMERKPWF
     501  DRNGNNKWGL RQYFSLSAAV ILISTIYAHC SS*

external links for Hfd1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Hfd1p

1)	Zahedi RP, et al. (2006) Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell 17(3):1436-50
2)	Nakahara K, et al. (2012) The sjogren-larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell 46(4):461-71
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41