PGM2/YMR105C Protein Information Help

Standard Name Pgm2p 1
Systematic Name Ymr105cp
Alias Gal5p 2
ORF Classification Verified
Description Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication (1, 3, 4, 5)
Name Description PhosphoGlucoMutase 6
Experimental Data
Molecules/cell 3790 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 569
Molecular Weight (Da) 63,088
Isoelectric Point (pI) 6.6

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pgm2p (InterPro)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000131854 | P37012
MIPS: YMR105C
NCBI: 438234 | 493064 | 51830486 | 548494 | 6323752 | 817863 | NP_013823.1 | NM_001182605.1
GenBank/EMBL/DDBJ: DAA10001.1 | AY723853 | U09499 | X74823 | Z49702
External Classifications EC: 5.4.2.2 [Phosphoglucomutase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSFQIETVPT KPYEDQKPGT SGLRKKTKVF KDEPNYTENF IQSIMEAIPE
      51  GSKGATLVVG GDGRYYNDVI LHKIAAIGAA NGIKKLVIGQ HGLLSTPAAS
     101  HIMRTYEEKC TGGIILTASH NPGGPENDMG IKYNLSNGGP APESVTNAIW
     151  EISKKLTSYK IIKDFPELDL GTIGKNKKYG PLLVDIIDIT KDYVNFLKEI
     201  FDFDLIKKFI DNQRSTKNWK LLFDSMNGVT GPYGKAIFVD EFGLPADEVL
     251  QNWHPSPDFG GMHPDPNLTY ASSLVKRVDR EKIEFGAASD GDGDRNMIYG
     301  YGPSFVSPGD SVAIIAEYAA EIPYFAKQGI YGLARSFPTS GAIDRVAKAH
     351  GLNCYEVPTG WKFFCALFDA KKLSICGEES FGTGSNHVRE KDGVWAIMAW
     401  LNILAIYNKH HPENEASIKT IQNEFWAKYG RTFFTRYDFE KVETEKANKI
     451  VDQLRAYVTK SGVVNSAFPA DESLKVTDCG DFSYTDLDGS VSDHQGLYVK
     501  LSNGARFVLR LSGTGSSGAT IRLYIEKYCD DKSQYQKTAE EYLKPIINSV
     551  IKFLNFKQVL GTEEPTVRT*

external links for Pgm2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Pgm2p
1) Boles E, et al.  (1994) A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem 220(1):83-96
2) Oh D and Hopper JE  (1990) Transcription of a yeast phosphoglucomutase isozyme gene is galactose inducible and glucose repressible. Mol Cell Biol 10(4):1415-22
3) Marchase RB, et al.  (1993) Phosphoglucomutase in Saccharomyces cerevisiae is a cytoplasmic glycoprotein and the acceptor for a Glc-phosphotransferase. J Biol Chem 268(11):8341-9
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Bevan P and Douglas HC  (1969) Genetic control of phosphoglucomutase variants in Saccharomyces cerevisiae. J Bacteriol 98(2):532-5
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41