YPK2/YMR104C Protein Information Help

Standard Name Ypk2p
Systematic Name Ymr104cp
Alias Ykr2p
ORF Classification Verified
Description Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK; YPK2 has a paralog, YPK1, that arose from the whole genome duplication (1, 2, 3)
Name Description Yeast Protein Kinase
Experimental Data
Molecules/cell 1310 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 677
Molecular Weight (Da) 76,664
Isoelectric Point (pI) 7.68

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ypk2p (InterPro)
Physical Interactions There are 33 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013BDFF | P18961
MIPS: YMR104C
NCBI: 140977 | 295681 | 6323751 | 817862 | NP_013822.1
GenBank/EMBL/DDBJ: DAA10000.1 | M24929 | Z49702
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MHSWRISKFK LGRSKEDDGS SEDENEKSWG NGLFHFHHGE KHHDGSPKNH
      51  NHEHEHHIRK INTNETLPSS LSSPKLRNDA SFKNPSGIGN DNSKASERKA
     101  SQSSTETQGP SSESGLMTVK VYSGKDFTLP FPITSNSTIL QKLLSSGILT
     151  SSSNDASEVA AIMRQLPRYK RVDQDSAGEG LIDRAFATKF IPSSILLPGS
     201  TNSSPLLYFT IEFDNSITTI SPDMGTMEQP VFNKISTFDV TRKLRFLKID
     251  VFARIPSLLL PSKNWQQEIG EQDEVLKEIL KKINTNQDIH LDSFHLPLNL
     301  KIDSAAQIRL YNHHWISLER GYGKLNITVD YKPSKNKPLS IDDFDLLKVI
     351  GKGSFGKVMQ VRKKDTQKIY ALKALRKAYI VSKCEVTHTL AERTVLARVD
     401  CPFIVPLKFS FQSPEKLYLV LAFINGGELF YHLQHEGRFS LARSRFYIAE
     451  LLCALDSLHK LDVIYRDLKP ENILLDYQGH IALCDFGLCK LNMKDNDKTD
     501  TFCGTPEYLA PEILLGQGYT KTVDWWTLGI LLYEMMTGLP PYYDENVPVM
     551  YKKILQQPLL FPDGFDPAAK DLLIGLLSRD PSRRLGVNGT DEIRNHPFFK
     601  DISWKKLLLK GYIPPYKPIV KSEIDTANFD QEFTKEKPID SVVDEYLSAS
     651  IQKQFGGWTY IGDEQLGDSP SQGRSIS*

external links for Ypk2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ypk2p
1) Casamayor A, et al.  (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol 9(4):186-97
2) Roelants FM, et al.  (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41