SRT1/YMR101C Protein Information

Standard Name	Srt1p
Systematic Name	Ymr101cp
ORF Classification	Verified
Description	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase (1, 2, 3)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	343
Molecular Weight (Da)	40,200
Isoelectric Point (pI)	10.3

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Srt1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000038E52 \| Q03175 MIPS: YMR101C NCBI: 2501565 \| 4126459 \| 6323748 \| 854438 \| NP_013819.1 GenBank/EMBL/DDBJ: DAA09998.1 \| AB013498 \| Z49807
External Classifications	EC: 2.5.1.- [Transferases transferring alkyl or aryl groups, other than methyl groups] EC: 2.5.1.87 [Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl]

Amino Acid Sequence (or in FASTA format)
1 MKMPSIIQIQ FVALKRLLVE TKEQMCFAVK SIFQRVFAWV MSLSLFSWFY 51 VNLQNILIKA LRVGPVPEHV SFIMDGNRRY AKSRRLPVKK GHEAGGLTLL 101 TLLYICKRLG VKCVSAYAFS IENFNRPKEE VDTLMNLFTV KLDEFAKRAK 151 DYKDPLYGSK IRIVGDQSLL SPEMRKKIKK VEEITQDGDD FTLFICFPYT 201 SRNDMLHTIR DSVEDHLENK SPRINIRKFT NKMYMGFHSN KCELLIRTSG 251 HRRLSDYMLW QVHENATIEF SDTLWPNFSF FAMYLMILKW SFFSTIQKYN 301 EKNHSLFEKI HESVPSIFKK KKTAMSLYNF PNPPISVSVT GDE*

Amino Acid Sequence (or in FASTA format)

       1  MKMPSIIQIQ FVALKRLLVE TKEQMCFAVK SIFQRVFAWV MSLSLFSWFY
      51  VNLQNILIKA LRVGPVPEHV SFIMDGNRRY AKSRRLPVKK GHEAGGLTLL
     101  TLLYICKRLG VKCVSAYAFS IENFNRPKEE VDTLMNLFTV KLDEFAKRAK
     151  DYKDPLYGSK IRIVGDQSLL SPEMRKKIKK VEEITQDGDD FTLFICFPYT
     201  SRNDMLHTIR DSVEDHLENK SPRINIRKFT NKMYMGFHSN KCELLIRTSG
     251  HRRLSDYMLW QVHENATIEF SDTLWPNFSF FAMYLMILKW SFFSTIQKYN
     301  EKNHSLFEKI HESVPSIFKK KKTAMSLYNF PNPPISVSVT GDE*

external links for Srt1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Srt1p

1)	Sato M, et al. (1999) The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis. Mol Cell Biol 19(1):471-83
2)	Schenk B, et al. (2001) An alternative cis-isoprenyltransferase activity in yeast that produces polyisoprenols with chain lengths similar to mammalian dolichols. Glycobiology 11(1):89-98
3)	Sato M, et al. (2001) Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis. Genes Cells 6(6):495-506