CTF18/YMR078C Protein Information Help

Standard Name Ctf18p
Systematic Name Ymr078cp
Alias Chl12p 1
ORF Classification Verified
Description Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint (2, 3)
Name Description Chromosome Transmission Fidelity 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 741
Molecular Weight (Da) 84,373
Isoelectric Point (pI) 8.46

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ctf18p (InterPro)
Physical Interactions There are 54 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530FD | P49956
MIPS: YMR078C
NCBI: 1705792 | 6323724 | 807960 | NP_013795.1
GenBank/EMBL/DDBJ: DAA09976.1 | L24514 | Z49259
Amino Acid Sequence (or in FASTA format)
 
       1  MVDTAPYIGS LGRSSLFDTG DIEQAPGNNA IGINEEDIHA FVSSTGETVQ
      51  LKKKPAKLAT GNISLYTNPD TVWRSDDTYG ININYLLDKI EASGDDRTNA
     101  QKTSPITGKI GSDTLWVEKW RPKKFLDLVG NEKTNRRMLG WLRQWTPAVF
     151  KEQLPKLPTE KEVSDMELDP LKRPPKKILL LHGPPGIGKT SVAHVIAKQS
     201  GFSVSEINAS DERAGPMVKE KIYNLLFNHT FDTNPVCLVA DEIDGSIESG
     251  FIRILVDIMQ SDIKATNKLL YGQPDKKDKK RKKKRSKLLT RPIICICNNL
     301  YAPSLEKLKP FCEIIAVKRP SDTTLLERLN LICHKENMNI PIKAINDLID
     351  LAQGDVRNCI NNLQFLASNV DSRDSSASDK PACAKNTWAS SNKDSPISWF
     401  KIVNQLFRKD PHRDIKEQFY ELLNQVELNG NSDRILQGCF NIFPYVKYSD
     451  NGIRKPANIS DWLFFHDLMY QSMYAHNGEL LRYSALVPLV FFQTFGDIAN
     501  KDDIRMKNSE YEQRELKRAN SDIVSLIMRH ISVQSPLMAS FTDRKSLIFE
     551  ILPYLDSMIS SDFNKIRNLK LKQAIMEELV QLLKSFQLNL IQNRSEGFDV
     601  RGGLTIDPPI DEVVLLNPKH INEVQHKRAN NLSSLLAKIE ENRAKKRHID
     651  QVTEDRLQSQ EMHSKKVKTG LNSSSSTIDF FKNQYGLLKQ TQELEETQKT
     701  IGSDETNQAD DCNQTVKIWV KYNEGFSNAV RKNVTWNNLW E*

external links for Ctf18p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ctf18p
1) Kouprina N, et al.  (1993) Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Yeast 9(1):11-9
2) Mayer ML, et al.  (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70
3) Naiki T, et al.  (2001) Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. Mol Cell Biol 21(17):5838-45
4) Spencer F, et al.  (1990) Mitotic chromosome transmission fidelity mutants in Saccharomyces cerevisiae. Genetics 124(2):237-49