PDS5/YMR076C Protein Information Help

Standard Name Pds5p
Systematic Name Ymr076cp
ORF Classification Verified
Description Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis (1, 2, 3)
Name Description Precocious Dissociation of Sisters 1
Experimental Data
Molecules/cell 7720 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,277
Molecular Weight (Da) 147,040
Isoelectric Point (pI) 6.2

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pds5p (InterPro)
Physical Interactions There are 58 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013BA37 | Q04264
MIPS: YMR076C
NCBI: 2497140 | 6323722 | 763023 | 807957 | NP_013793.1
GenBank/EMBL/DDBJ: DAA09974.1 | Z48952 | Z49259
Amino Acid Sequence (or in FASTA format)
 
       1  MAKGAVTKLK FNSPIISTSD QLISTNELLD RLKALHEELA SLDQDNTDLT
      51  GLDKYRDALV SRKLLKHKDV GIRAFTACCL SDILRLYAPD APYTDAQLTD
     101  IFKLVLSQFE QLGDQENGYH IQQTYLITKL LEYRSIVLLA DLPSSNNLLI
     151  ELFHIFYDPN KSFPARLFNV IGGILGEVIS EFDSVPLEVL RLIFNKFLTY
     201  NPNEIPEGLN VTSDCGYEVS LILCDTYSNR MSRHLTKYYS EIIHEATNDD
     251  NNSRLLTVVV KLHKLVLRLW ETVPELINAV IGFIYHELSS ENELFRKEAT
     301  KLIGQILTSY SDLNFVSTHS DTFKAWISKI ADISPDVRVE WTESIPQIIA
     351  TREDISKELN QALAKTFIDS DPRVRRTSVM IFNKVPVTEI WKNITNKAIY
     401  TSLLHLAREK HKEVRELCIN TMAKFYSNSL NEIERTYQNK EIWEIIDTIP
     451  STLYNLYYIN DLNINEQVDS VIFEYLLPFE PDNDKRVHRL LTVLSHFDKK
     501  AFTSFFAFNA RQIKISFAIS KYIDFSKFLN NQESMSSSQG PIVMNKYNQT
     551  LQWLASGLSD STKAIDALET IKQFNDERIF YLLNACVTND IPFLTFKNCY
     601  NELVSKLQTP GLFKKYNIST GASIMPRDIA KVIQILLFRA SPIIYNVSNI
     651  SVLLNLSNNS DAKQLDLKRR ILDDISKVNP TLFKDQIRTL KTIIKDLDDP
     701  DAEKNDNLSL EEALKTLYKA SKTLKDQVDF DDTFFFTKLY DFAVESKPEI
     751  TKYATKLIAL SPKAEETLKK IKIRILPLDL QKDKYFTSHI IVLMEIFKKF
     801  PHVLNDDSTD IISYLIKEVL LSNQVVGDSK KEIDWVEDSL LSDTKYSAIG
     851  NKVFTLKLFT NKLRSIAPDV PRDELAESFT EKTMKLFFYL IASGGELISE
     901  FNKEFYPTPS NYQTKLRCVA GIQVLKLARI SNLNNFIKPS DIIKLINLVE
     951  DESLPVRKTF LEQLKDYVAN ELISIKFLPL VFFTAYEPDV ELKTTTKIWI
    1001  NFTFGLKSFK KGTIFERALP RLIHAIAHHP DIVGGLDSEG DAYLNALTTA
    1051  IDYLLFYFDS IAAQENFSLL YYLSERVKNY QDKLVEDEID EEEGPQKEEA
    1101  PKKHRPYGQK MYIIGELSQM ILLNLKEKKN WQHSAYPGKL NLPSDLFKPF
    1151  ATVQEAQLSF KTYIPESLTE KIQNNIKAKI GRILHTSQTQ RQRLQKRLLA
    1201  HENNESQKKK KKVHHARSQA DDEEGDGDRE SDSDDDSYSP SNKNETKKGH
    1251  ENIVMKKLRV RKEVDYKDDE DDDIEMT*

external links for Pds5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Pds5p
1) Hartman T, et al.  (2000) Pds5p is an essential chromosomal protein required for both sister chromatid cohesion and condensation in Saccharomyces cerevisiae. J Cell Biol 151(3):613-26
2) Panizza S, et al.  (2000) Pds5 cooperates with cohesin in maintaining sister chromatid cohesion. Curr Biol 10(24):1557-64
3) Zhang Z, et al.  (2005) Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Mol Microbiol 56(3):670-80
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41