SAM37/YMR060C Protein Information

Standard Name	Sam37p 1
Systematic Name	Ymr060cp
Alias	Mas37p 2 , Pet3027p 2 , Tom37p 3
ORF Classification	Verified
Description	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability (4, 5)
Name Description	Sorting and Assembly Machinery 1

Experimental Data
Molecules/cell	1580 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	327
Molecular Weight (Da)	37,493
Isoelectric Point (pI)	7.32

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sam37p (InterPro)
Physical Interactions	There are 15 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000130CB4 \| P50110 MIPS: YMR060C NCBI: 1709461 \| 45269868 \| 6323705 \| 773583 \| 817893 \| NP_013776.1 GenBank/EMBL/DDBJ: DAA09958.1 \| AY557989 \| X62565 \| Z49703

Amino Acid Sequence (or in FASTA format)
1 MVKGSVHLWG KDGKASLISV DSIALVWFIK LCTSEEAKSM VAGLQIVFSN 51 NTDLSSDGKL PVLILDNGTK VSGYVNIVQF LHKNICTSKY EKGTDYEEDL 101 AIVRKKDRLL EYSLLNYVDV EISRLTDYQL FLNTKNYNEY TKKLFSKLLY 151 FPMWYNTPLQ LRSQARENCE EIIGSLTLED DEEFVESKAM ESASQLAQSK 201 TFKIAHKNKI KGKQELQQVK YNLQFDNRLQ SCVSNWLAAR KKLDDSVILS 251 SDLLFLANLY VQLGLPDGNR IRSKLEQTFG SELLNSMSNK IDDFVHRPSN 301 NLEQRDPQFR EQGNVVMSLY NLACKYI*

Amino Acid Sequence (or in FASTA format)

       1  MVKGSVHLWG KDGKASLISV DSIALVWFIK LCTSEEAKSM VAGLQIVFSN
      51  NTDLSSDGKL PVLILDNGTK VSGYVNIVQF LHKNICTSKY EKGTDYEEDL
     101  AIVRKKDRLL EYSLLNYVDV EISRLTDYQL FLNTKNYNEY TKKLFSKLLY
     151  FPMWYNTPLQ LRSQARENCE EIIGSLTLED DEEFVESKAM ESASQLAQSK
     201  TFKIAHKNKI KGKQELQQVK YNLQFDNRLQ SCVSNWLAAR KKLDDSVILS
     251  SDLLFLANLY VQLGLPDGNR IRSKLEQTFG SELLNSMSNK IDDFVHRPSN
     301  NLEQRDPQFR EQGNVVMSLY NLACKYI*

external links for Sam37p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome
	GeneMANIA

References cited on this page View Complete Literature Guide for Sam37p

1)	Pfanner N, et al. (2004) Assembling the mitochondrial outer membrane. Nat Struct Mol Biol 11(11):1044-8
2)	Gratzer S, et al. (1995) Mas37p, a novel receptor subunit for protein import into mitochondria. J Cell Biol 129(1):25-34
3)	Pfanner N, et al. (1996) Uniform nomenclature for the protein transport machinery of the mitochondrial membranes. Trends Biochem Sci 21(2):51-2
4)	Wiedemann N, et al. (2003) Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424(6948):565-71
5)	Meisinger C, et al. (2004) The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev Cell 7(1):61-71
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41