MSN2/YMR037C Protein Information Help

Standard Name Msn2p 1
Systematic Name Ymr037cp
ORF Classification Verified
Description Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress (2, 3, 4, 5)
Name Description Multicopy suppressor of SNF1 mutation 1
Experimental Data
Molecules/cell 125 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 704
Molecular Weight (Da) 77,860
Isoelectric Point (pI) 6.55

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Msn2p (InterPro)
Physical Interactions There are 25 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012F623 | P33748
MIPS: YMR037C
NCBI: 349595 | 462625 | 6323680 | 695717 | NP_013751.1
GenBank/EMBL/DDBJ: DAA09936.1 | L08838 | Z48502
Amino Acid Sequence (or in FASTA format)
 
       1  MTVDHDFNSE DILFPIESMS SIQYVENNNP NNINNDVIPY SLDIKNTVLD
      51  SADLNDIQNQ ETSLNLGLPP LSFDSPLPVT ETIPSTTDNS LHLKADSNKN
     101  RDARTIENDS EIKSTNNASG SGANQYTTLT SPYPMNDILY NMNNPLQSPS
     151  PSSVPQNPTI NPPINTASNE TNLSPQTSNG NETLISPRAQ QHTSIKDNRL
     201  SLPNGANSNL FIDTNPNNLN EKLRNQLNSD TNSYSNSISN SNSNSTGNLN
     251  SSYFNSLNID SMLDDYVSSD LLLNDDDDDT NLSRRRFSDV ITNQFPSMTN
     301  SRNSISHSLD LWNHPKINPS NRNTNLNITT NSTSSSNASP NTTTMNANAD
     351  SNIAGNPKNN DATIDNELTQ ILNEYNMNFN DNLGTSTSGK NKSACPSSFD
     401  ANAMTKINPS QQLQQQLNRV QHKQLTSSHN NSSTNMKSFN SDLYSRRQRA
     451  SLPIIDDSLS YDLVNKQDED PKNDMLPNSN LSSSQQFIKP SMILSDNASV
     501  IAKVATTGLS NDMPFLTEEG EQNANSTPNF DLSITQMNMA PLSPASSSST
     551  SLATNHFYHH FPQQGHHTMN SKIGSSLRRR KSAVPLMGTV PLTNQQNNIS
     601  SSSVNSTGNG AGVTKERRPS YRRKSMTPSR RSSVVIESTK ELEEKPFHCH
     651  ICPKSFKRSE HLKRHVRSVH SNERPFACHI CDKKFSRSDN LSQHIKTHKK
     701  HGDI*

external links for Msn2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Msn2p
1) Estruch F and Carlson M  (1993) Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae. Mol Cell Biol 13(7):3872-81
2) Martinez-Pastor MT, et al.  (1996) The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J 15(9):2227-35
3) Gorner W, et al.  (1998) Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev 12(4):586-97
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41