UBC7/YMR022W Protein Information Help

Standard Name Ubc7p 1
Systematic Name Ymr022wp
Alias Qri8p 2 , Der2p 3
ORF Classification Verified
Description Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly (4, 5)
Name Description UBiquitin-Conjugating enzyme 1
Experimental Data
Molecules/cell 2100 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 165
Molecular Weight (Da) 18,520
Isoelectric Point (pI) 4.9

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ubc7p (InterPro)
Physical Interactions There are 22 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000036C82 | Q02159
MIPS: YMR022W
NCBI: 157836399 | 401242 | 4257 | 45270122 | 5523 | 6323664 | 798933 | NP_013735.1
GenBank/EMBL/DDBJ: DAA09920.1 | AY558116 | X66829 | X69100 | Z49211
External Classifications EC: 6.3.2.19 [Ubiquitin--protein ligase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSKTAQKRLL KELQQLIKDS PPGIVAGPKS ENNIFIWDCL IQGPPDTPYA
      51  DGVFNAKLEF PKDYPLSPPK LTFTPSILHP NIYPNGEVCI SILHSPGDDP
     101  NMYELAEERW SPVQSVEKIL LSVMSMLSEP NIESGANIDA CILWRDNRPE
     151  FERQVKLSIL KSLGF*

external links for Ubc7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ubc7p
1) Jungmann J, et al.  (1993) Resistance to cadmium mediated by ubiquitin-dependent proteolysis. Nature 361(6410):369-71
2) Vassal A, et al.  (1992) QRI8, a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae. Biochim Biophys Acta 1132(2):211-3
3) Hiller MM, et al.  (1996) ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science 273(5282):1725-8
4) Biederer T, et al.  (1997) Role of Cue1p in ubiquitination and degradation at the ER surface. Science 278(5344):1806-9
5) Arnason TG, et al.  (2005) Novel interaction between Apc5p and Rsp5p in an intracellular signaling pathway in Saccharomyces cerevisiae. Eukaryot Cell 4(1):134-46
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41