FMS1/YMR020W Protein Information

Standard Name	Fms1p
Systematic Name	Ymr020wp
ORF Classification	Verified
Description	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis (1, 2, 3)
Name Description	Fenpropimorph-resistance Multicopy Suppressor

Experimental Data
Molecules/cell	6960 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	508
Molecular Weight (Da)	57,805
Isoelectric Point (pI)	5.45

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fms1p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012AAD8 \| P50264 MIPS: YMR020W NCBI: 1143556 \| 164414888 \| 164414889 \| 164414890 \| 164414891 \| 164414892 \| 164414893 \| 166235484 \| 166235485 \| 166235486 \| 166235487 \| 1706879 \| 185178010 \| 185178011 \| 185178012 \| 185178013 \| 185178014 \| 185178015 \| 185178016 \| 185178017 \| 185178018 \| 185178019 \| 390981120 \| 390981121 \| 409107306 \| 409107307 \| 409107308 \| 409107309 \| 61679815 \| 61679816 \| 62738830 \| 62738831 \| 6323662 \| 66360552 \| 66360553 \| 66360554 \| 66360555 \| 78101041 \| 78101042 \| 798930 \| NP_013733.1 GenBank/EMBL/DDBJ: DAA09918.1 \| X81848 \| Z49211

Amino Acid Sequence (or in FASTA format)
1 MNTVSPAKKK VIIIGAGIAG LKAASTLHQN GIQDCLVLEA RDRVGGRLQT 51 VTGYQGRKYD IGASWHHDTL TNPLFLEEAQ LSLNDGRTRF VFDDDNFIYI 101 DEERGRVDHD KELLLEIVDN EMSKFAELEF HQHLGVSDCS FFQLVMKYLL 151 QRRQFLTNDQ IRYLPQLCRY LELWHGLDWK LLSAKDTYFG HQGRNAFALN 201 YDSVVQRIAQ SFPQNWLKLS CEVKSITREP SKNVTVNCED GTVYNADYVI 251 ITVPQSVLNL SVQPEKNLRG RIEFQPPLKP VIQDAFDKIH FGALGKVIFE 301 FEECCWSNES SKIVTLANST NEFVEIVRNA ENLDELDSML EREDSQKHTS 351 VTCWSQPLFF VNLSKSTGVA SFMMLMQAPL TNHIESIRED KERLFSFFQP 401 VLNKIMKCLD SEDVIDGMRP IENIANANKP VLRNIIVSNW TRDPYSRGAY 451 SACFPGDDPV DMVVAMSNGQ DSRIRFAGEH TIMDGAGCAY GAWESGRREA 501 TRISDLLK*

Amino Acid Sequence (or in FASTA format)

       1  MNTVSPAKKK VIIIGAGIAG LKAASTLHQN GIQDCLVLEA RDRVGGRLQT
      51  VTGYQGRKYD IGASWHHDTL TNPLFLEEAQ LSLNDGRTRF VFDDDNFIYI
     101  DEERGRVDHD KELLLEIVDN EMSKFAELEF HQHLGVSDCS FFQLVMKYLL
     151  QRRQFLTNDQ IRYLPQLCRY LELWHGLDWK LLSAKDTYFG HQGRNAFALN
     201  YDSVVQRIAQ SFPQNWLKLS CEVKSITREP SKNVTVNCED GTVYNADYVI
     251  ITVPQSVLNL SVQPEKNLRG RIEFQPPLKP VIQDAFDKIH FGALGKVIFE
     301  FEECCWSNES SKIVTLANST NEFVEIVRNA ENLDELDSML EREDSQKHTS
     351  VTCWSQPLFF VNLSKSTGVA SFMMLMQAPL TNHIESIRED KERLFSFFQP
     401  VLNKIMKCLD SEDVIDGMRP IENIANANKP VLRNIIVSNW TRDPYSRGAY
     451  SACFPGDDPV DMVVAMSNGQ DSRIRFAGEH TIMDGAGCAY GAWESGRREA
     501  TRISDLLK*

external links for Fms1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Fms1p

1)	White WH, et al. (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800
2)	Landry J and Sternglanz R (2003) Yeast Fms1 is a FAD-utilizing polyamine oxidase. Biochem Biophys Res Commun 303(3):771-6
3)	Chattopadhyay MK, et al. (2003) Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Proc Natl Acad Sci U S A 100(24):13869-74
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41