COS3/YML132W Protein Information Help

Standard Name Cos3p
Systematic Name Yml132wp
ORF Classification Verified
Description Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (1, 2)
Name Description COnserved Sequence
Experimental Data
Molecules/cell 639 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 379
Molecular Weight (Da) 45,165
Isoelectric Point (pI) 8.64

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cos3p (InterPro)
Transmembrane Domains There are 4 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004F952 | P0CX13
MIPS: YML132W
NCBI: 338817767 | 6319779 | 6323503 | 927530 | NP_009861.1 | NP_013574.1
GenBank/EMBL/DDBJ: DAA09767.1 | Z50178
Amino Acid Sequence (or in FASTA format)
 
       1  MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
      51  IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS
     101  KQLIQFCKEI TENTPSSDPH DWEVVAANLN SYLYENNVWN TKYFFFNAMV
     151  CQEAFRTTLL EPFSLKKDKA AKVKSFKDSV PYIEEALGVY FTEVEKQWKL
     201  FNTEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
     251  VSRGMCLLLR TLYLGWILFM LVQGFQNIRV LIMSMEHKMQ FLSTIINEQE
     301  SGANGWDEIA RKMNRYLFEK KAWKNEEFFF DGIDCEWFFN HFFYRVLSAK
     351  KSMWPLPLNV ELWPYIKEAQ LSRSEVLLV*

external links for Cos3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Cos3p
1) Spode I, et al.  (2002) ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. J Mol Biol 319(2):407-20
2) Despons L, et al.  (2006) An evolutionary scenario for one of the largest yeast gene families. Trends Genet 22(1):10-5
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41