YML131W Protein Information Help

Systematic Name Yml131wp
ORF Classification Verified
Description Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress (1, 10, 2, 3, 4, 5, 6, 7, 8, 9)
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 365
Molecular Weight (Da) 39,976
Isoelectric Point (pI) 8.32

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Yml131wp (InterPro)
Transmembrane Domains There are 2 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 14 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B9F7 | Q03102
MIPS: YML131W
NCBI: 2497058 | 45269874 | 6323504 | 927531 | NP_013575.1
GenBank/EMBL/DDBJ: DAA09768.1 | AY557992 | Z50178
Amino Acid Sequence (or in FASTA format)
 
       1  MVLAKQWVLK NLPTPGEPFN FHFHDPACTF ELIEKELSSE QLKDGELLLE
      51  TTYLSNDPAQ KFWISSMDKN YAKGVQPGEI IPARGIGKVL ASRNKAFSPG
     101  DYVSAVTGWT THAIISQENV QGLRKLDKNK VGKLWWYLSV LGGTSLTAYF
     151  IFFTYAQLQE REEDYGKVYL ISGAAGAVGT VCIQLALNVF KASKVIAIAG
     201  GPEKVAFVES FGDNVVGVDY KDPSFKQKLI EAAGGENTVD YFIDNVGSNV
     251  LEAGVLLLKQ RAMLIACGAI SAYNDPSKFV FKGYSFILTK RLVVKGVLVT
     301  DNIDDFPKAL DKLGSLVKHG KIDLLKSATL EDGTGDKFKN VPLIWKGLFS
     351  GVNKGKLITK VNNEE*

external links for Yml131wp
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Yml131wp
1) Rep M, et al.  (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83
2) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3) Jelinsky SA and Samson LD  (1999) Global response of Saccharomyces cerevisiae to an alkylating agent. Proc Natl Acad Sci U S A 96(4):1486-91
4) Riveros-Rosas H, et al.  (2003) Diversity, taxonomy and evolution of medium-chain dehydrogenase/reductase superfamily. Eur J Biochem 270(16):3309-34
5) Nordling E, et al.  (2002) Medium-chain dehydrogenases/reductases (MDR). Family characterizations including genome comparisons and active site modeling. Eur J Biochem 269(17):4267-76
6) Lee MW, et al.  (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
7) Iwahashi H, et al.  (2007) Evaluation of toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray. BMC Genomics 8:95
8) Del Vescovo V, et al.  (2008) Role of Hog1 and Yaf9 in the transcriptional response of Saccharomyces cerevisiae to cesium chloride. Physiol Genomics 33(1):110-20
9) Trott A, et al.  (2008) Activation of Heat Shock and Antioxidant Responses by the Natural Product Celastrol: Transcriptional Signatures of a Thiol-targeted Molecule. Mol Biol Cell 19(3):1104-12
10) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76