PGA3/YML125C Protein Information Help

Standard Name Pga3p 1
Systematic Name Yml125cp
Alias Nqr1p 2
ORF Classification Verified
Description Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Processing of Gas1p and ALP 1
Experimental Data
Molecules/cell 29000 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 312
Molecular Weight (Da) 35,287
Isoelectric Point (pI) 5.31

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pga3p (InterPro)
Transmembrane Domains There are 2 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B9F5 | Q12746
MIPS: YML125C
NCBI: 2498064 | 6323510 | 805017 | 927537 | NP_013581.1 | NM_001182488.1
GenBank/EMBL/DDBJ: CAA89155.1 | CAA90558.1 | DAA09774.1 | Z49218 | Z50178
External Classifications EC: 1.-.-.- [Oxidoreductases]
EC: 1.6.-.- [Oxidoreductases, Acting on NADH or NADPH]
EC: 1.6.2.2 [Cytochrome-b5 reductase]
Amino Acid Sequence (or in FASTA format)
       1  MSKEDIEGTN ILDEPVHGIY IPAALFVVGV AITTYMSGEL KILWSLPILF
      51  MIIFVRAYSA YKRRRSLYPD RWTSLELEDQ TIISKNTALY RFKLKTRLES
     101  LDIPAGHHVA VRVPIDGKQE VRYYNPISSK LESGYLDLVV KAYVDGKVSK
     151  YFAGLNSGDT VDFKGPIGTL NYEPNSSKHL GIVAGGSGIT PVLQILNEII
     201  TVPEDLTKVS LLYANETEND ILLKDELDEM AEKYPHFQVH YVVHYPSDRW
     251  TGDVGYITKD QMNRYLPEYS EDNRLLICGP DGMNNLALQY AKELGWKVNS
     301  TRSSGDDQVF VF*                                        

external links for Pga3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains YeastRC Public Image Repository
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Pga3p
1) Yu L, et al.  (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47
2) Jimenez-Hidalgo M, et al.  (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41