PGA3/YML125C Protein Information

Standard Name	Pga3p 1
Systematic Name	Yml125cp
Alias	Nqr1p 2
ORF Classification	Verified
Description	Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Processing of Gas1p and ALP 1

Experimental Data
Molecules/cell	29000 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	312
Molecular Weight (Da)	35,287
Isoelectric Point (pI)	5.31

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pga3p (InterPro)
Transmembrane Domains	There are 2 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B9F5 \| Q12746 MIPS: YML125C NCBI: 2498064 \| 6323510 \| 805017 \| 927537 \| NP_013581.1 \| NM_001182488.1 GenBank/EMBL/DDBJ: DAA09774.1 \| Z49218 \| Z50178
External Classifications	EC: 1.-.-.- [Oxidoreductases] EC: 1.6.-.-

Amino Acid Sequence (or in FASTA format)
1 MSKEDIEGTN ILDEPVHGIY IPAALFVVGV AITTYMSGEL KILWSLPILF 51 MIIFVRAYSA YKRRRSLYPD RWTSLELEDQ TIISKNTALY RFKLKTRLES 101 LDIPAGHHVA VRVPIDGKQE VRYYNPISSK LESGYLDLVV KAYVDGKVSK 151 YFAGLNSGDT VDFKGPIGTL NYEPNSSKHL GIVAGGSGIT PVLQILNEII 201 TVPEDLTKVS LLYANETEND ILLKDELDEM AEKYPHFQVH YVVHYPSDRW 251 TGDVGYITKD QMNRYLPEYS EDNRLLICGP DGMNNLALQY AKELGWKVNS 301 TRSSGDDQVF VF*

Amino Acid Sequence (or in FASTA format)

       1  MSKEDIEGTN ILDEPVHGIY IPAALFVVGV AITTYMSGEL KILWSLPILF
      51  MIIFVRAYSA YKRRRSLYPD RWTSLELEDQ TIISKNTALY RFKLKTRLES
     101  LDIPAGHHVA VRVPIDGKQE VRYYNPISSK LESGYLDLVV KAYVDGKVSK
     151  YFAGLNSGDT VDFKGPIGTL NYEPNSSKHL GIVAGGSGIT PVLQILNEII
     201  TVPEDLTKVS LLYANETEND ILLKDELDEM AEKYPHFQVH YVVHYPSDRW
     251  TGDVGYITKD QMNRYLPEYS EDNRLLICGP DGMNNLALQY AKELGWKVNS
     301  TRSSGDDQVF VF*

external links for Pga3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Pga3p

1)	Yu L, et al. (2006) A survey of essential gene function in the yeast cell division cycle. Mol Biol Cell 17(11):4736-47
2)	Jimenez-Hidalgo M, et al. (2009) NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell 8(2):140-51
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41