TUB3/YML124C Protein Information Help

Standard Name Tub3p
Systematic Name Yml124cp
ORF Classification Verified
Description Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication (1, 2)
Name Description TUBulin
Experimental Data
Molecules/cell 12300 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 445
Molecular Weight (Da) 49,694
Isoelectric Point (pI) 4.92

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tub3p (InterPro)
Physical Interactions There are 59 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052ED6 | P09734
MIPS: YML124C
NCBI: 135419 | 173061 | 6323511 | 805018 | NP_013582.1 | NM_001182487.1
GenBank/EMBL/DDBJ: AAA35181.1 | CAA89156.1 | DAA09775.1 | D90346 | M28428 | Z49218
Amino Acid Sequence (or in FASTA format)
       1  MREVISINVG QAGCQIGNAC WELYSLEHGI KEDGHLEDGL SKPKGGEEGF
      51  STFFHETGYG KFVPRAIYVD LEPNVIDEVR TGRFKELFHP EQLINGKEDA
     101  ANNYARGHYT VGREIVDEVE ERIRKMADQC DGLQGFLFTH SLGGGTGSGL
     151  GSLLLENLSY EYGKKSKLEF AVYPAPQLST SVVEPYNTVL TTHTTLEHAD
     201  CTFMVDNEAI YDICKRNLGI SRPSFSNLNG LIAQVISSVT ASLRFDGSLN
     251  VDLNEFQTNL VPYPRIHFPL VSYAPILSKK RATHESNSVS EITNACFEPG
     301  NQMVKCDPTK GKYMANCLLY RGDVVTRDVQ RAVEQVKNKK TVQMVDWCPT
     351  GFKIGICYEP PSVIPSSELA NVDRAVCMLS NTTAIADAWK RIDQKFDLMY
     401  AKRAFVHWYV GEGMEEGEFT EAREDLAALE RDYIEVGADS YAEEF*    

external links for Tub3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
YGOB CYC2008 (complexes) MIPS YPL+
YOGY Complexome Pfam domains YeastGFP

DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Tub3p
1) Schatz PJ, et al.  (1986) Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins. Mol Cell Biol 6(11):3722-33
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41