GTR1/YML121W Protein Information

Standard Name	Gtr1p 1
Systematic Name	Yml121wp
ORF Classification	Verified
Description	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB (1, 2, 3, 4, 5, 6, 7)
Name Description	GTp binding protein Resemblance 1

Experimental Data
Molecules/cell	907 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	310
Molecular Weight (Da)	35,847
Isoelectric Point (pI)	8.34

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gtr1p (InterPro)
Physical Interactions	There are 75 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012BD02 \| Q00582 MIPS: YML121W NCBI: 218431 \| 344189683 \| 344189685 \| 400261192 \| 417096 \| 51013285 \| 6323514 \| 805021 \| NP_013585.1 GenBank/EMBL/DDBJ: DAA09777.1 \| AY692917 \| D10018 \| Z49218

Amino Acid Sequence (or in FASTA format)
1 MSSNNRKKLL LMGRSGSGKS SMRSIIFSNY SAFDTRRLGA TIDVEHSHLR 51 FLGNMTLNLW DCGGQDVFME NYFTKQKDHI FQMVQVLIHV FDVESTEVLK 101 DIEIFAKALK QLRKYSPDAK IFVLLHKMDL VQLDKREELF QIMMKNLSET 151 SSEFGFPNLI GFPTSIWDES LYKAWSQIVC SLIPNMSNHQ SNLKKFKEIM 201 NALEIILFER TTFLVICSSN GENSNENHDS SDNNNVLLDP KRFEKISNIM 251 KNFKQSCTKL KSGFKTLILN NNIYVSELSS NMVCFIVLKD MNIPQELVLE 301 NIKKAKEFFQ *

Amino Acid Sequence (or in FASTA format)

       1  MSSNNRKKLL LMGRSGSGKS SMRSIIFSNY SAFDTRRLGA TIDVEHSHLR
      51  FLGNMTLNLW DCGGQDVFME NYFTKQKDHI FQMVQVLIHV FDVESTEVLK
     101  DIEIFAKALK QLRKYSPDAK IFVLLHKMDL VQLDKREELF QIMMKNLSET
     151  SSEFGFPNLI GFPTSIWDES LYKAWSQIVC SLIPNMSNHQ SNLKKFKEIM
     201  NALEIILFER TTFLVICSSN GENSNENHDS SDNNNVLLDP KRFEKISNIM
     251  KNFKQSCTKL KSGFKTLILN NNIYVSELSS NMVCFIVLKD MNIPQELVLE
     301  NIKKAKEFFQ *

external links for Gtr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gtr1p

1)	Bun-Ya M, et al. (1992) Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol 12(7):2958-66
2)	Nakashima N, et al. (1996) Putative GTPase Gtr1p genetically interacts with the RanGTPase cycle in Saccharomyces cerevisiae. J Cell Sci 109 ( Pt 9):2311-8
3)	Nakashima N, et al. (1999) Saccharomyces cerevisiae putative G protein, Gtr1p, which forms complexes with itself and a novel protein designated as Gtr2p, negatively regulates the Ran/Gsp1p G protein cycle through Gtr2p. Genetics 152(3):853-67
4)	Hirose E, et al. (1998) RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway. J Cell Sci 111 ( Pt 1):11-21
5)	Palecek SP, et al. (2000) Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae. Genetics 156(3):1005-23
6)	Gao M and Kaiser CA (2006) A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast. Nat Cell Biol 8(7):657-67
7)	Sekiguchi T, et al. (2008) Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae. Biochem Biophys Res Commun 368(3):748-54
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41