ATR1/YML116W Protein Information Help

Standard Name Atr1p
Systematic Name Yml116wp
Alias Snq1p
ORF Classification Verified
Description Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description AminoTriazole Resistance 1
Experimental Data
Molecules/cell 1720 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 542
Molecular Weight (Da) 59,983
Isoelectric Point (pI) 7.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Atr1p (InterPro)
Transmembrane Domains There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012661B | P13090
MIPS: YML116W
NCBI: 1703757 | 171124 | 51830476 | 6323520 | 798884 | NP_013591.1
GenBank/EMBL/DDBJ: DAA09782.1 | AY723850 | M20319 | Z49210
External Classifications TC: 2.A.1.3 [The Drug:H+ Antiporter-2 (14 Spanner) (DHA2) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MGNQSLVVLT ESKGEYENET ELPVKKSSRD NNIGESLTAT AFTQSEDEMV
      51  DSNQKWQNPN YFKYAWQEYL FIFTCMISQL LNQAGTTQTL SIMNILSDSF
     101  GSEGNSKSWL MASFPLVSGS FILISGRLGD IYGLKKMLLV GYVLVIIWSL
     151  ICGITKYSGS DTFFIISRAF QGLGIAFVLP NVLGIIGNIY VGGTFRKNIV
     201  ISFVGAMAPI GATLGCLFAG LIGTEDPKQW PWAFYAYSIA AFINFVLSIY
     251  AIPSTIPTNI HHFSMDWIGS VLGVIGLILL NFVWNQAPIS GWNQAYIIVI
     301  LIISVIFLVV FIIYEIRFAK TPLLPRAVIK DRHMIQIMLA LFFGWGSFGI
     351  FTFYYFQFQL NIRQYTALWA GGTYFMFLIW GIIAALLVGF TIKNVSPSVF
     401  LFFSMVAFNV GSIMASVTPV HETYFRTQLG TMIILSFGMD LSFPASSIIF
     451  SDNLPMEYQG MAGSLVNTVV NYSMSLCLGM GATVETQVNS DGKHLLKGYR
     501  GAQYLGIGLA SLACMISGLY MVESFIKGRR ARAAAEYDCT VA*

external links for Atr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Atr1p
1) Kanazawa S, et al.  (1988) ATR1, a Saccharomyces cerevisiae gene encoding a transmembrane protein required for aminotriazole resistance. Mol Cell Biol 8(2):664-73
2) Goffeau A, et al.  (1997) Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily. Yeast 13(1):43-54
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41