COQ5/YML110C Protein Information

Standard Name	Coq5p
Systematic Name	Yml110cp
Alias	Dbi56p
ORF Classification	Verified
Description	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes (1, 2, 3)
Name Description	COenzyme Q
Gene Product	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase 1

Experimental Data
Molecules/cell	8100 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	307
Molecular Weight (Da)	34,684
Isoelectric Point (pI)	6.52

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Coq5p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000127EFE \| P49017 MIPS: YML110C NCBI: 1353083 \| 51013839 \| 6323526 \| 798890 \| NP_013597.1 GenBank/EMBL/DDBJ: DAA09788.1 \| AY693194 \| Z49210
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases] EC: 2.1.1.201 [2-methoxy-6-polyprenyl-1,4-benzoquinol methylase]

Amino Acid Sequence (or in FASTA format)
1 MLISSRIVRS SLVNVPLRLS RCFTQAHRAC KEEEVNSPLS SAAEQPEQKY 51 THFGSKTVLK STKQKLVGDV FSSVANRYDL MNDVMSLGIH RLWKDHFINK 101 LDAGKRPNST TPLNFIDVAG GSGDIAFGLL DHAESKFGDT ESTMDIVDIN 151 PDMLKEGEKR AMEQGKYFKD PRVRFLVSNG EKLEEIDSDS KDIYTVSFGI 201 RNFTDIQKGL NTAYRVLKPG GIFYCLEFSK IENPLMDFAY QQWAKVLPVM 251 GSMIANDYDS YQYLVESIER FPDQETFKSM IEKAGFKSAG YESLTFGICA 301 IHWGIKV*

Amino Acid Sequence (or in FASTA format)

       1  MLISSRIVRS SLVNVPLRLS RCFTQAHRAC KEEEVNSPLS SAAEQPEQKY
      51  THFGSKTVLK STKQKLVGDV FSSVANRYDL MNDVMSLGIH RLWKDHFINK
     101  LDAGKRPNST TPLNFIDVAG GSGDIAFGLL DHAESKFGDT ESTMDIVDIN
     151  PDMLKEGEKR AMEQGKYFKD PRVRFLVSNG EKLEEIDSDS KDIYTVSFGI
     201  RNFTDIQKGL NTAYRVLKPG GIFYCLEFSK IENPLMDFAY QQWAKVLPVM
     251  GSMIANDYDS YQYLVESIER FPDQETFKSM IEKAGFKSAG YESLTFGICA
     301  IHWGIKV*

external links for Coq5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Coq5p

1)	Dibrov E, et al. (1997) The COQ5 gene encodes a yeast mitochondrial protein necessary for ubiquinone biosynthesis and the assembly of the respiratory chain. J Biol Chem 272(14):9175-81
2)	Barkovich RJ, et al. (1997) Characterization of the COQ5 gene from Saccharomyces cerevisiae. Evidence for a C-methyltransferase in ubiquinone biosynthesis. J Biol Chem 272(14):9182-8
3)	Hsieh EJ, et al. (2007) Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex. Arch Biochem Biophys 463(1):19-26
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41