AIM33/YML087C Protein Information

Standard Name	Aim33p 1
Systematic Name	Yml087cp
ORF Classification	Verified
Description	Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication (1, 2, 3)
Name Description	Altered Inheritance rate of Mitochondria 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	312
Molecular Weight (Da)	35,763
Isoelectric Point (pI)	8.87

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aim33p (InterPro)
Transmembrane Domains	There are 2 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B9D4 \| Q04516 MIPS: YML087C NCBI: 2498065 \| 575716 \| 6323552 \| NP_013623.1 GenBank/EMBL/DDBJ: DAA09810.1 \| Z46660
External Classifications	EC: 1.-.-.- [Oxidoreductases]

Amino Acid Sequence (or in FASTA format)
1 MSIVETCISF VSTNPFYPFC TGLLLNCVVT PLYFWKTQNG RIVVVSLLQF 51 VVLYATAFIS IGTDKSLYRN KWVALPLSKK TRISRNTSLY CFKLKYPFER 101 LHIPMGYHLA VRVTINGERL VRYYTPVNVP NTEGHLELVV KTYKHGVVSK 151 YFDKLKIRQY VEFKGPLGEL EYDQDTATEL GIIAGGSGIT PVLQVLQEII 201 PSPEDLTHIS LIYANETEDD ILMKSQLDHM AKEYPHFKVH YVIHKPNGKW 251 NGDVGYVTLE EMKRYLPKQA EDHRLLICGP PKMNEMVLNY AKELGWSNGF 301 HKGNGTDKVF VF*

Amino Acid Sequence (or in FASTA format)

       1  MSIVETCISF VSTNPFYPFC TGLLLNCVVT PLYFWKTQNG RIVVVSLLQF
      51  VVLYATAFIS IGTDKSLYRN KWVALPLSKK TRISRNTSLY CFKLKYPFER
     101  LHIPMGYHLA VRVTINGERL VRYYTPVNVP NTEGHLELVV KTYKHGVVSK
     151  YFDKLKIRQY VEFKGPLGEL EYDQDTATEL GIIAGGSGIT PVLQVLQEII
     201  PSPEDLTHIS LIYANETEDD ILMKSQLDHM AKEYPHFKVH YVIHKPNGKW
     251  NGDVGYVTLE EMKRYLPKQA EDHRLLICGP PKMNEMVLNY AKELGWSNGF
     301  HKGNGTDKVF VF*

external links for Aim33p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Aim33p

1)	Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Heinicke S, et al. (2007) The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. PLoS One 2(8):e766