DUS1/YML080W Protein Information

Standard Name	Dus1p
Systematic Name	Yml080wp
ORF Classification	Verified
Description	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 (1)
Name Description	DihydroUridine Synthase 1

Experimental Data
Molecules/cell	1860 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	423
Molecular Weight (Da)	48,131
Isoelectric Point (pI)	9.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dus1p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B9D0 \| P53759 MIPS: YML080W NCBI: 1730621 \| 587531 \| 6323560 \| NP_013631.1 GenBank/EMBL/DDBJ: DAA09817.1 \| Z46373
External Classifications	EC: 1.-.-.- [Oxidoreductases] EC: 1.3.1.88 [tRNA-dihydrouridine(16/17) synthase (NAD(P)(+))]

Amino Acid Sequence (or in FASTA format)
1 MTEPALSSAN NALMQKLTGR QLFDKIGRPT RIVAPMVDQS ELAWRILSRR 51 YGATLAYTPM LHAKLFATSK KYREDNWSSL DGSSVDRPLV VQFCANDPEY 101 LLAAAKLVED KCDAVDLNLG CPQGIAKKGH YGSFLMEEWD LIHNLINTLH 151 KNLKVPVTAK IRIFDDCEKS LNYAKMVLDA GAQFLTVHGR VREQKGQKTG 201 LANWETIKYL RDNLPKETVF FANGNILYPE DISRCMEHIG ADAVMSAEGN 251 LYNPGVFNVG QTKNKEKIFP RVDKIIREYF QIVKECQESK ASKTAMKSHF 301 FKILRPFLPH HTDIRSTLAT MNAKATWEEW EEQVVKPVEK VVQEIFEQPD 351 IAIKDEITIG EKQSWGGSYR TVPYWRCQPY FRPVNGITGD KRVMQGLIDE 401 SVNKKRKADV PLESADKKKD VKA*

Amino Acid Sequence (or in FASTA format)

       1  MTEPALSSAN NALMQKLTGR QLFDKIGRPT RIVAPMVDQS ELAWRILSRR
      51  YGATLAYTPM LHAKLFATSK KYREDNWSSL DGSSVDRPLV VQFCANDPEY
     101  LLAAAKLVED KCDAVDLNLG CPQGIAKKGH YGSFLMEEWD LIHNLINTLH
     151  KNLKVPVTAK IRIFDDCEKS LNYAKMVLDA GAQFLTVHGR VREQKGQKTG
     201  LANWETIKYL RDNLPKETVF FANGNILYPE DISRCMEHIG ADAVMSAEGN
     251  LYNPGVFNVG QTKNKEKIFP RVDKIIREYF QIVKECQESK ASKTAMKSHF
     301  FKILRPFLPH HTDIRSTLAT MNAKATWEEW EEQVVKPVEK VVQEIFEQPD
     351  IAIKDEITIG EKQSWGGSYR TVPYWRCQPY FRPVNGITGD KRVMQGLIDE
     401  SVNKKRKADV PLESADKKKD VKA*

external links for Dus1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Dus1p

1)	Xing F, et al. (2002) A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA 8(3):370-81
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41