RPL6A/YML073C Protein Information

Standard Name	Rpl6ap
Systematic Name	Yml073cp
Alias	Yl16ap
ORF Classification	Verified
Description	Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description	Ribosomal Protein of the Large subunit
Gene Product	L17A 4 , L6A 4 , L6e 7 , YL16 4 , rp18 4

Experimental Data
Molecules/cell	37100 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	176
Molecular Weight (Da)	19,961
Isoelectric Point (pI)	10.91

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpl6ap (InterPro)
Physical Interactions	There are 130 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001683B9 \| Q02326 MIPS: YML073C NCBI: 218509 \| 315113305 \| 315113531 \| 315113576 \| 365767256 \| 365767297 \| 410562483 \| 417576 \| 6323567 \| 914877 \| NP_013638.1 GenBank/EMBL/DDBJ: DAA09824.1 \| D10225 \| Z46373

Amino Acid Sequence (or in FASTA format)
1 MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK 51 RVVYLKHLED NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK 101 FNVEYFAKEK LTKKEKKEAN LFPEQQNKEI KAERVEDQKV VDKALIAEIK 151 KTPLLKQYLS ASFSLKNGDK PHMLKF*

Amino Acid Sequence (or in FASTA format)

       1  MSAQKAPKWY PSEDVAALKK TRKAARPQKL RASLVPGTVL ILLAGRFRGK
      51  RVVYLKHLED NTLLISGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK
     101  FNVEYFAKEK LTKKEKKEAN LFPEQQNKEI KAERVEDQKV VDKALIAEIK
     151  KTPLLKQYLS ASFSLKNGDK PHMLKF*

external links for Rpl6ap

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Rpl6ap

1)	Arnold RJ, et al. (1999) The action of N-terminal acetyltransferases on yeast ribosomal proteins. J Biol Chem 274(52):37035-40
2)	Hashimoto T, et al. (1992) Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16. Biochim Biophys Acta 1132(2):195-8
3)	Lee JC, et al. (1983) Binding of proteins from the large ribosomal subunits to 5.8 S rRNA of Saccharomyces cerevisiae. J Biol Chem 258(2):854-8
4)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
5)	Lecompte O, et al. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
6)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41