ORC1/YML065W Protein Information Help

Standard Name Orc1p 1
Systematic Name Yml065wp
ORF Classification Verified
Description Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication (2, 3, 4)
Name Description Origin Recognition Complex 5
Experimental Data
Molecules/cell 3930 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 914
Molecular Weight (Da) 104,399
Isoelectric Point (pI) 5.45

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Orc1p (InterPro)
Physical Interactions There are 439 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000531B0 | P54784
MIPS: YML065W
NCBI: 1065911 | 1709488 | 24158940 | 24158941 | 558410 | 6323575 | 71042259 | 71042303 | NP_013646.1 | NM_001182424.1
GenBank/EMBL/DDBJ: AAB38248.1 | CAA86256.1 | DAA09832.1 | U34860 | Z38114
Amino Acid Sequence (or in FASTA format)
       1  MAKTLKDLQG WEIITTDEQG NIIDGGQKRL RRRGAKTEHY LKRSSDGIKL
      51  GRGDSVVMHN EAAGTYSVYM IQELRLNTLN NVVELWALTY LRWFEVNPLA
     101  HYRQFNPDAN ILNRPLNYYN KLFSETANKN ELYLTAELAE LQLFNFIRVA
     151  NVMDGSKWEV LKGNVDPERD FTVRYICEPT GEKFVDINIE DVKAYIKKVE
     201  PREAQEYLKD LTLPSKKKEI KRGPQKKDKA TQTAQISDAE TRATDITDNE
     251  DGNEDESSDY ESPSDIDVSE DMDSGEISAD ELEEEEDEEE DEDEEEKEAR
     301  HTNSPRKRGR KIKLGKDDID ASVQPPPKKR GRKPKDPSKP RQMLLISSCR
     351  ANNTPVIRKF TKKNVARAKK KYTPFSKRFK SIAAIPDLTS LPEFYGNSSE
     401  LMASRFENKL KTTQKHQIVE TIFSKVKKQL NSSYVKEEIL KSANFQDYLP
     451  ARENEFASIY LSAYSAIESD SATTIYVAGT PGVGKTLTVR EVVKELLSSS
     501  AQREIPDFLY VEINGLKMVK PTDCYETLWN KVSGERLTWA ASMESLEFYF
     551  KRVPKNKKKT IVVLLDELDA MVTKSQDIMY NFFNWTTYEN AKLIVIAVAN
     601  TMDLPERQLG NKITSRIGFT RIMFTGYTHE ELKNIIDLRL KGLNDSFFYV
     651  DTKTGNAILI DAAGNDTTVK QTLPEDVRKV RLRMSADAIE IASRKVASVS
     701  GDARRALKVC KRAAEIAEKH YMAKHGYGYD GKTVIEDENE EQIYDDEDKD
     751  LIESNKAKDD NDDDDDNDGV QTVHITHVMK ALNETLNSHV ITFMTRLSFT
     801  AKLFIYALLN LMKKNGSQEQ ELGDIVDEIK LLIEVNGSNK FVMEIAKTLF
     851  QQGSDNISEQ LRIISWDFVL NQLLDAGILF KQTMKNDRIC CVKLNISVEE
     901  AKRAMNEDET LRNL*                                      

external links for Orc1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Orc1p
1) Bell SP, et al.  (1995) The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83(4):563-8
2) Klemm RD, et al.  (1997) Coordinate binding of ATP and origin DNA regulates the ATPase activity of the origin recognition complex. Cell 88(4):493-502
3) Bell SP  (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Bell SP and Stillman B  (1992) ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357(6374):128-34
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41