SML1/YML058W Protein Information Help

Standard Name Sml1p 1
Systematic Name Yml058wp
ORF Classification Verified
Description Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication (2, 3, 4)
Name Description Suppressor of Mec1 Lethality 1
Experimental Data
Molecules/cell 18800 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 104
Molecular Weight (Da) 11,834
Isoelectric Point (pI) 4.55

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sml1p (InterPro)
Physical Interactions There are 54 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B9AE | Q04964
MIPS: YML058W
NCBI: 2497086 | 45269814 | 577138 | 6323582 | NP_013653.1 | NM_001182417.1
GenBank/EMBL/DDBJ: DAA09840.1 | AY557961 | Z46729
Amino Acid Sequence (or in FASTA format)
 
       1  MQNSQDYFYA QNRCQQQQAP STLRTVTMAE FRRVPLPPMA EVPMLSTQNS
      51  MGSSASASAS SLEMWEKDLE ERLNSIDHDM NNNKFGSGEL KSMFNQGKVE
     101  EMDF*

external links for Sml1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome


DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Sml1p
1) Zhao X, et al.  (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell 2(3):329-40
2) Chabes A, et al.  (1999) Yeast Sml1, a protein inhibitor of ribonucleotide reductase. J Biol Chem 274(51):36679-83
3) Zhao X and Rothstein R  (2002) The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1. Proc Natl Acad Sci U S A 99(6):3746-51
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41