GAL80/YML051W Protein Information

Standard Name	Gal80p 1
Systematic Name	Yml051wp
ORF Classification	Verified
Description	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding (2)
Name Description	GALactose metabolism

Experimental Data
Molecules/cell	784 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	435
Molecular Weight (Da)	48,323
Isoelectric Point (pI)	8.16

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gal80p (InterPro)
Physical Interactions	There are 87 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012B07C \| P04387 MIPS: YML051W NCBI: 169404709 \| 169404710 \| 169404713 \| 169404714 \| 169404715 \| 169404716 \| 169404717 \| 169404718 \| 169404719 \| 169404720 \| 1730189 \| 3718 \| 374977798 \| 374977799 \| 577146 \| 6323590 \| 642304 \| NP_013661.1 GenBank/EMBL/DDBJ: DAA09848.1 \| X01667 \| Z46729 \| Z47816

Amino Acid Sequence (or in FASTA format)
1 MDYNKRSSVS TVPNAAPIRV GFVGLNAAKG WAIKTHYPAI LQLSSQFQIT 51 ALYSPKIETS IATIQRLKLS NATAFPTLES FASSSTIDMI VIAIQVASHY 101 EVVMPLLEFS KNNPNLKYLF VEWALACSLD QAESIYKAAA ERGVQTIISL 151 QGRKSPYILR AKELISQGYI GDINSIEIAG NGGWYGYERP VKSPKYIYEI 201 GNGVDLVTTT FGHTIDILQY MTSSYFSRIN AMVFNNIPEQ ELIDERGNRL 251 GQRVPKTVPD HLLFQGTLLN GNVPVSCSFK GGKPTKKFTK NLVIDIHGTK 301 GDLKLEGDAG FAEISNLVLY YSGTRANDFP LANGQQAPLD PGYDAGKEIM 351 EVYHLRNYNA IVGNIHRLYQ SISDFHFNTK KIPELPSQFV MQGFDFEGFP 401 TLMDALILHR LIESVYKSNM MGSTLNVSNI SHYSL*

Amino Acid Sequence (or in FASTA format)

       1  MDYNKRSSVS TVPNAAPIRV GFVGLNAAKG WAIKTHYPAI LQLSSQFQIT
      51  ALYSPKIETS IATIQRLKLS NATAFPTLES FASSSTIDMI VIAIQVASHY
     101  EVVMPLLEFS KNNPNLKYLF VEWALACSLD QAESIYKAAA ERGVQTIISL
     151  QGRKSPYILR AKELISQGYI GDINSIEIAG NGGWYGYERP VKSPKYIYEI
     201  GNGVDLVTTT FGHTIDILQY MTSSYFSRIN AMVFNNIPEQ ELIDERGNRL
     251  GQRVPKTVPD HLLFQGTLLN GNVPVSCSFK GGKPTKKFTK NLVIDIHGTK
     301  GDLKLEGDAG FAEISNLVLY YSGTRANDFP LANGQQAPLD PGYDAGKEIM
     351  EVYHLRNYNA IVGNIHRLYQ SISDFHFNTK KIPELPSQFV MQGFDFEGFP
     401  TLMDALILHR LIESVYKSNM MGSTLNVSNI SHYSL*

external links for Gal80p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Gal80p

1)	Hopper JE and Rowe LB (1978) Molecular expression and regulation of the galactose pathway genes in Saccharomyces cerevisiae. Distinct messenger RNAs specified by the Gali and Gal7 genes in the Gal7-Gal10-Gal1 cluster. J Biol Chem 253(20):7566-9
2)	Timson DJ, et al. (2002) Gal3p and Gal1p interact with the transcriptional repressor Gal80p to form a complex of 1:1 stoichiometry. Biochem J 363(Pt 3):515-20
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41