RSE1/YML049C Protein Information

Standard Name	Rse1p
Systematic Name	Yml049cp
ORF Classification	Verified
Description	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport (1, 2)
Name Description	RNA Splicing and ER to Golgi transport

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,361
Molecular Weight (Da)	153,783
Isoelectric Point (pI)	5.69

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rse1p (InterPro)
Physical Interactions	There are 116 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000530F0 \| Q04693 MIPS: YML049C NCBI: 2497090 \| 6323592 \| 642306 \| NP_013663.1 GenBank/EMBL/DDBJ: DAA09850.1 \| Z47816

Amino Acid Sequence (or in FASTA format)
1 MWGGGKMAVV SLSPHTAKMR KLFGQASTTM AYDGLKREAE RRTRSDHNIT 51 MVAKDDELYL YHLTLKKQTN FVHSCIGHFV DLEAGSKREQ SQLCVATETH 101 LELYDTADGE LKLIAKFQNL FATITSMKSL DLPHSGSRAK ASNWPTFLAL 151 TSDSGNLSIV QIIMHAGALR LKTLVNQPLT RTTLRRVSPI SYMEIDPNGR 201 CIILSSVEQN KLCFLVDYAQ KLRISSPLEI IRPHMVTLDM AVVDVNFNNP 251 CFVTLEIDNA ATQLSVHLIF YVLELGLNHI VKKADYLVNP SANFVLSLPD 301 LSRYNITTSL SDNNYDADYD TLFNPFVVIG FENHILVKDM NGFFSLKVEI 351 PKRSITNSRH KNVTIISGIV QKLKNDFFVL LQSNHGDLFK LTVSPDTNDR 401 NRPLVQLSYF DTIQNSHQLH IFKNGYLFAL SEMNNNFLFQ FEKLGVEKND 451 FSNVLTSKDP NKSLVFEPSI KLQNLSILSQ QLNLNPSIKS QIVSDSPLSI 501 ATKHFTNNKI ITLTNAVNYS NLISTSLPPN ATKLWLIPDP ATTGDNNTLL 551 FITFPKKTMI LQIDNESMEE LTPDEATRSA FKLSQDTTIH TCLMGSHSII 601 QVCTAELRHI VPTGKSRYSN KLTWVPPAGI RIVCATSSKT QLIISLSNYE 651 LVYFKIDVSS DSLIELTTHP ELDTMPSKVA IVQDTQHADL LAIADNEGMI 701 KIMSLKDQKE DFLTVISLQL VSEKISDMIM VRDSSIGQLN LHVGLENGVY 751 MKFHIGDVDG SFTDIKRRFL GLKPVSLSYL REISVSLNNE EEEEEEEDDD 801 DEKEEEEINS SGAKWMSCVV CHSSSTWVSY TWKNVWTIRQ LKDQNMLSCS 851 KFVNADVAIN GVCSISSSGR LNIGRVSNFP TLDNWFHVHE SSVNKQENGG 901 GDESNEEEED EMEEEMEMLQ ISTFRPRTIL SFPNNPKSIL FIDNHSGKKQ 951 CRISLQIDGE CLKFGSSDHL YKILDDIDCV SAAIIDFTRQ ADHLIICAGD 1001 KRLLTYKILV NKDKLSFDIE LLHQTEIISP IHAMLKFKNF LLTAMGSTIV 1051 LYGLGKKQLL RRSVTQTPVS ITKIVSMHQW NYERLAVGDI HESVTLFIWD 1101 PAGNVFIPYV DDSVKRHVTV LKFLDEATVI GADRYGNAWT LRSPPECEKI 1151 MSNHDPSELS NGAIKYPLDV ITLQQKLPNT YDCKFKFQLL NHFFVNDIIT 1201 DFHILDSLSN SDRPGCIYMG LQGTVGCFIP LLSKGNVFMM GNIENIMAEA 1251 DDTFYLDYES RKKNNNMRKE DDEEESGSVV LQGRHGIEDE IICEGSCSIL 1301 GRDHQEYRSY YAPVRKVIDG DLCENFLRLS LNEQEFLAKN LKSVQVEDII 1351 QTINEVRTNY M*

Amino Acid Sequence (or in FASTA format)

       1  MWGGGKMAVV SLSPHTAKMR KLFGQASTTM AYDGLKREAE RRTRSDHNIT
      51  MVAKDDELYL YHLTLKKQTN FVHSCIGHFV DLEAGSKREQ SQLCVATETH
     101  LELYDTADGE LKLIAKFQNL FATITSMKSL DLPHSGSRAK ASNWPTFLAL
     151  TSDSGNLSIV QIIMHAGALR LKTLVNQPLT RTTLRRVSPI SYMEIDPNGR
     201  CIILSSVEQN KLCFLVDYAQ KLRISSPLEI IRPHMVTLDM AVVDVNFNNP
     251  CFVTLEIDNA ATQLSVHLIF YVLELGLNHI VKKADYLVNP SANFVLSLPD
     301  LSRYNITTSL SDNNYDADYD TLFNPFVVIG FENHILVKDM NGFFSLKVEI
     351  PKRSITNSRH KNVTIISGIV QKLKNDFFVL LQSNHGDLFK LTVSPDTNDR
     401  NRPLVQLSYF DTIQNSHQLH IFKNGYLFAL SEMNNNFLFQ FEKLGVEKND
     451  FSNVLTSKDP NKSLVFEPSI KLQNLSILSQ QLNLNPSIKS QIVSDSPLSI
     501  ATKHFTNNKI ITLTNAVNYS NLISTSLPPN ATKLWLIPDP ATTGDNNTLL
     551  FITFPKKTMI LQIDNESMEE LTPDEATRSA FKLSQDTTIH TCLMGSHSII
     601  QVCTAELRHI VPTGKSRYSN KLTWVPPAGI RIVCATSSKT QLIISLSNYE
     651  LVYFKIDVSS DSLIELTTHP ELDTMPSKVA IVQDTQHADL LAIADNEGMI
     701  KIMSLKDQKE DFLTVISLQL VSEKISDMIM VRDSSIGQLN LHVGLENGVY
     751  MKFHIGDVDG SFTDIKRRFL GLKPVSLSYL REISVSLNNE EEEEEEEDDD
     801  DEKEEEEINS SGAKWMSCVV CHSSSTWVSY TWKNVWTIRQ LKDQNMLSCS
     851  KFVNADVAIN GVCSISSSGR LNIGRVSNFP TLDNWFHVHE SSVNKQENGG
     901  GDESNEEEED EMEEEMEMLQ ISTFRPRTIL SFPNNPKSIL FIDNHSGKKQ
     951  CRISLQIDGE CLKFGSSDHL YKILDDIDCV SAAIIDFTRQ ADHLIICAGD
    1001  KRLLTYKILV NKDKLSFDIE LLHQTEIISP IHAMLKFKNF LLTAMGSTIV
    1051  LYGLGKKQLL RRSVTQTPVS ITKIVSMHQW NYERLAVGDI HESVTLFIWD
    1101  PAGNVFIPYV DDSVKRHVTV LKFLDEATVI GADRYGNAWT LRSPPECEKI
    1151  MSNHDPSELS NGAIKYPLDV ITLQQKLPNT YDCKFKFQLL NHFFVNDIIT
    1201  DFHILDSLSN SDRPGCIYMG LQGTVGCFIP LLSKGNVFMM GNIENIMAEA
    1251  DDTFYLDYES RKKNNNMRKE DDEEESGSVV LQGRHGIEDE IICEGSCSIL
    1301  GRDHQEYRSY YAPVRKVIDG DLCENFLRLS LNEQEFLAKN LKSVQVEDII
    1351  QTINEVRTNY M*

external links for Rse1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Rse1p

1)	Caspary F, et al. (1999) Partial purification of the yeast U2 snRNP reveals a novel yeast pre-mRNA splicing factor required for pre-spliceosome assembly. EMBO J 18(12):3463-74
2)	Chen EJ, et al. (1998) A link between secretion and pre-mRNA processing defects in Saccharomyces cerevisiae and the identification of a novel splicing gene, RSE1. Mol Cell Biol 18(12):7139-46