NSE5/YML023C Protein Information Help

Standard Name Nse5p 1
Systematic Name Yml023cp
ORF Classification Verified
Description Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair (1, 2)
Name Description Non-SMC Element 5 1
Experimental Data
Molecules/cell 907 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 556
Molecular Weight (Da) 64,012
Isoelectric Point (pI) 5.88

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Nse5p (InterPro)
Physical Interactions There are 28 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B97B | Q03718
MIPS: YML023C
NCBI: 2497102 | 575696 | 6323618 | NP_013689.1
GenBank/EMBL/DDBJ: DAA09875.1 | Z46659
Amino Acid Sequence (or in FASTA format)
 
       1  MDGALINSVL YVSPRNGAHY FVELTEKHLL AFEMLNSMCL LENYDHVLLF
      51  LECQFGKSHN LAVIPFDIIL VLFTLSTLSE YYKEPILRAN DPYNTSRETL
     101  SRRALKLLQK YLAILKEFDS EQYNLYDLEL LRCQFFLAID TLTPKKQKWG
     151  FDRFRRTKSE SGVTYRQNAS VDPELDQAKT FKNPYRSYIS CLEQRNTILG
     201  NRLLNLKLNE PGEFINMILW TLSNSLQEST PLFLSSHEIW MPLLEILIDL
     251  FSCRQDYFIQ HEVAQNVSKS LFVQRLSESP LAVFFESLNT RNFANRFSEY
     301  VFLNCDYKLP SDNYATPVHP VYNGENTIVD TYIPTIKCSP LYKSQKSLAL
     351  RRKLIGSCFK LLLRVPDGHR LITPRIVADD VIQGISRTLA SFNDILQFKK
     401  FFMTENLSQE SYFIPLLAEG TLSEILKDTQ ECVVILTLVE NLSDGVSFCN
     451  EVIGLVKSKC FAFTEQCSQA SYEEAVLNIE KCDVCLLVLL RYLLHLIGTE
     501  AILDAKEQLE MLHAIEKNDS GRRQWAKALN LGNDPPLLYP IVSQMFGVHD
     551  KSVIIE*

external links for Nse5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome


DIP


GeneMANIA


YeastRC Mass Spec (Seattle)


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Nse5p
1) Zhao X and Blobel G  (2005) A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization. Proc Natl Acad Sci U S A 102(13):4777-82
2) Bermudez-Lopez M, et al.  (2010) The Smc5/6 complex is required for dissolution of DNA-mediated sister chromatid linkages. Nucleic Acids Res 38(19):6502-12
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41