YRF1-4/YLR466W Protein Information

Standard Name	Yrf1-4p
Systematic Name	Ylr466wp
Alias	Yrf1p
ORF Classification	Verified
Description	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p (1, 2)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,382
Molecular Weight (Da)	156,366
Isoelectric Point (pI)	7.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yrf1-4p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BFD0 \| O13559 MIPS: YLR466W NCBI: 17380337 \| 2264354 \| 398366389 \| NP_013571.3 GenBank/EMBL/DDBJ: DAA09763.1 \| U22383
External Classifications	EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]

Amino Acid Sequence (or in FASTA format)
1 MWKTLGRVEQ LLPYASLILR NREVLFREPK RGIDEYLEND SFFQMIPVKY 51 REIVLPKLRR DTNKMTAALK NKVAVAIDEL TVPLMWMIHF AVGYPYRYPE 101 LQLLAFAGPQ RNVYVDDTTR RIQLYTDYNK NGSSEPRLKT LDGLTSDYVF 151 YFVTVLRQMQ ICALGNSYDA FNHDPWMDVV GFEDPDQVTN RDISRIVLYS 201 YMFLNTAKGC LVEYATFRQY MRELPKNAPQ KLNFREMRQG LIALGRHCVG 251 SRFETDLYES ATSELMANHS VQTGRNIYGV DSFSLTSVSG TTATLLQERA 301 SERWIQWLGL ESDYHCSFSS TRNAEDVVAG EAASSDHHQK ISRVTRKRPR 351 EPKSTNDILV AGRKLFGSSF EFRDLHQLRL CHEIYMADTP SVAVQAPPGY 401 GKTELFHLPL IALASKGDVK YVSFLFVPYT VLLANCMIRL SRCGCLNVAP 451 VRNFIEEGCD GVTDLYVGIY DDLASTNFTD RIAAWENIVE CTFRTNNVKL 501 GYLIVDEFHN FETEVYRQSQ FGGITNLDFD AFEKAIFLSG TAPEAVADAA 551 LQRIGLTGLA KKSMDINELK RSEDLSRGLS SYPTRMFNLI KEKSEVPLGH 601 VHKIWKKVES QPEEALKLLL ALFEIEPESK AIVVASTTNE VEELACSWRK 651 YFRVVWIHGK LGAAEKVSRT KEFVTDGSMR VLIGTKLVTE GIDIKQLMMV 701 IMLDNRLNII ELIQGVGRLR DGGLCYLLSR KNSWAARNRK GELPPIKEGC 751 ITEQVREFYG LESKKGKKGQ HVGCCGSRTD LSADTVELIE RMDRLAEKQA 801 TASMSIIALP SSFQESNSSD RCRKYCSSDE DSDTCIHGSA NASTNATTNS 851 STNATTTAST NVRTSATTTA SINVRTSAIT TESTNSSTNA TTTASTNVRT 901 SATTTASINV RTSATTTEST NSNTSATTTE STDSNTSATT TESTDSNTSA 951 TTTASTNSST NATTTASTNS STNATTTEST NASAKEDANK DGNAEDNRFH 1001 PVTDINKESY KRKGSQMVLL ERKKLKAQFP NTSENMNVLQ FLGFRSDEIK 1051 HLFLYGIDVY FCPEGVFTQY GLCKGCQKMF ELCVCWAGQK VSYRRMAWEA 1101 LAVERMLRND EEYKEYLEDI EPYHGDPVGY LKYFSVKRGE IYSQIQRNYA 1151 WYLAITRRRE TISVLDSTRG KQGSQVFRMS GRQIKELYYK VWSNLRESKT 1201 EVLQYFLNWD EKKCREEWEA KDDTVFVEAL EKVGVFQRLR SMTSAGLQGP 1251 QYVKLQFSRH HRQLRSRYEL SLGMHLRDQL ALGVTPSKVP HWTAFLSMLI 1301 GLFYNKTFRQ KLEYLLEQIS EVWLLPHWLD LANVEVLAAD NTRVPLYMLM 1351 VAVHKELDSD DVPDGRFDII LLCRDSSREV GE*

Amino Acid Sequence (or in FASTA format)

       1  MWKTLGRVEQ LLPYASLILR NREVLFREPK RGIDEYLEND SFFQMIPVKY
      51  REIVLPKLRR DTNKMTAALK NKVAVAIDEL TVPLMWMIHF AVGYPYRYPE
     101  LQLLAFAGPQ RNVYVDDTTR RIQLYTDYNK NGSSEPRLKT LDGLTSDYVF
     151  YFVTVLRQMQ ICALGNSYDA FNHDPWMDVV GFEDPDQVTN RDISRIVLYS
     201  YMFLNTAKGC LVEYATFRQY MRELPKNAPQ KLNFREMRQG LIALGRHCVG
     251  SRFETDLYES ATSELMANHS VQTGRNIYGV DSFSLTSVSG TTATLLQERA
     301  SERWIQWLGL ESDYHCSFSS TRNAEDVVAG EAASSDHHQK ISRVTRKRPR
     351  EPKSTNDILV AGRKLFGSSF EFRDLHQLRL CHEIYMADTP SVAVQAPPGY
     401  GKTELFHLPL IALASKGDVK YVSFLFVPYT VLLANCMIRL SRCGCLNVAP
     451  VRNFIEEGCD GVTDLYVGIY DDLASTNFTD RIAAWENIVE CTFRTNNVKL
     501  GYLIVDEFHN FETEVYRQSQ FGGITNLDFD AFEKAIFLSG TAPEAVADAA
     551  LQRIGLTGLA KKSMDINELK RSEDLSRGLS SYPTRMFNLI KEKSEVPLGH
     601  VHKIWKKVES QPEEALKLLL ALFEIEPESK AIVVASTTNE VEELACSWRK
     651  YFRVVWIHGK LGAAEKVSRT KEFVTDGSMR VLIGTKLVTE GIDIKQLMMV
     701  IMLDNRLNII ELIQGVGRLR DGGLCYLLSR KNSWAARNRK GELPPIKEGC
     751  ITEQVREFYG LESKKGKKGQ HVGCCGSRTD LSADTVELIE RMDRLAEKQA
     801  TASMSIIALP SSFQESNSSD RCRKYCSSDE DSDTCIHGSA NASTNATTNS
     851  STNATTTAST NVRTSATTTA SINVRTSAIT TESTNSSTNA TTTASTNVRT
     901  SATTTASINV RTSATTTEST NSNTSATTTE STDSNTSATT TESTDSNTSA
     951  TTTASTNSST NATTTASTNS STNATTTEST NASAKEDANK DGNAEDNRFH
    1001  PVTDINKESY KRKGSQMVLL ERKKLKAQFP NTSENMNVLQ FLGFRSDEIK
    1051  HLFLYGIDVY FCPEGVFTQY GLCKGCQKMF ELCVCWAGQK VSYRRMAWEA
    1101  LAVERMLRND EEYKEYLEDI EPYHGDPVGY LKYFSVKRGE IYSQIQRNYA
    1151  WYLAITRRRE TISVLDSTRG KQGSQVFRMS GRQIKELYYK VWSNLRESKT
    1201  EVLQYFLNWD EKKCREEWEA KDDTVFVEAL EKVGVFQRLR SMTSAGLQGP
    1251  QYVKLQFSRH HRQLRSRYEL SLGMHLRDQL ALGVTPSKVP HWTAFLSMLI
    1301  GLFYNKTFRQ KLEYLLEQIS EVWLLPHWLD LANVEVLAAD NTRVPLYMLM
    1351  VAVHKELDSD DVPDGRFDII LLCRDSSREV GE*

external links for Yrf1-4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Yrf1-4p

1)	Yamada M, et al. (1998) Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. J Biol Chem 273(50):33360-6
2)	Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64