RIF2/YLR453C Protein Information Help

Standard Name Rif2p 1
Systematic Name Ylr453cp
ORF Classification Verified
Description Protein that binds to the Rap1p C-terminus; acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; RIF2 has a paralog, ORC4, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description Rap1p-Interacting Factor 1
Experimental Data
Molecules/cell 589 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 395
Molecular Weight (Da) 45,643
Isoelectric Point (pI) 9.9

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rif2p (InterPro)
Physical Interactions There are 7 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001338EF | Q06208
MIPS: YLR453C
NCBI: 27805711 | 398366349 | 51013171 | 513137139 | 513137140 | 513137143 | 513137146 | 717069 | NP_013558.3 | NM_001182341.3
GenBank/EMBL/DDBJ: AAB67535.1 | AAT92879.1 | DAA09753.1 | AY692860 | U22382
Amino Acid Sequence (or in FASTA format)
       1  MEHVDSDFAP IRRSKKVVDS DKIVKAISDD LEQKNFTVLR KLNLVPIKKS
      51  VSSPKVCKPS PVKERVDHVF YQKFKSMALQ ELGTNYLSIS YVPSLSKFLS
     101  KNLRSMKNCI VFFDKVEHIH QYAGIDRAVS ETLSLVDINV VIIEMNDYLM
     151  KEGIQSSKSK ECIESMGQAS YSGQLDFEAS EKPSNHTSDL MMMVMRKINN
     201  DESIDHIVYF KFEQLDKLST STIIEPSKLT EFINVLSVLE KSNNIAFKVL
     251  IYSNNVSISS LLSTSLKKKL NTKYTVFEMP ILTCAQEQEY LKKMIKFTFD
     301  SGSKLLQSYN SLVTCQLNNK ESNLAIFFEF LKVFPHPFTY LFNAYTEIIV
     351  QSRTFDELLD KIRNRLTIKN YPHSAYNFKK NQRLPLKLTR KVHDR*    

external links for Rif2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains YeastRC Public Image Repository

DIP


GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rif2p
1) Hardy CF, et al.  (1992) A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 6(5):801-14
2) Wotton D and Shore D  (1997) A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae. Genes Dev 11(6):748-60
3) Teixeira MT, et al.  (2004) Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 117(3):323-35
4) Smogorzewska A and de Lange T  (2004) Regulation of telomerase by telomeric proteins. Annu Rev Biochem 73:177-208
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41