IMD3/YLR432W Protein Information

Standard Name	Imd3p 1
Systematic Name	Ylr432wp
ORF Classification	Verified
Description	Inosine monophosphate dehydrogenase; catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication (2, 3)
Name Description	IMP Dehydrogenase 1

Experimental Data
Molecules/cell	26300 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	523
Molecular Weight (Da)	56,584
Isoelectric Point (pI)	7.38

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Imd3p (InterPro)
Physical Interactions	There are 116 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012D604 \| P50095 MIPS: YLR432W NCBI: 1708477 \| 398366255 \| 665971 \| NP_013536.3 GenBank/EMBL/DDBJ: DAA09733.1 \| U21094
External Classifications	EC: 1.1.1.205 [IMP dehydrogenase]

Amino Acid Sequence (or in FASTA format)
1 MAAVRDYKTA LEFAKSLPRL DGLSVQELMD SKTRGGLTYN DFLVLPGLVD 51 FPSSEVSLQT KLTRNITLNT PFVSSPMDTV TESEMAIFMA LLGGIGFIHH 101 NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KERFGFSGFP 151 VTEDGKRNGK LMGIVTSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG 201 NEILKKIKKG KLLIVDDNGN LVSMLSRTDL MKNQNYPLAS KSATTKQLLC 251 GAAIGTIDAD KERLRLLVEA GLDVVILDSS QGNSIFQLNM IKWIKETFPD 301 LEIIAGNVAT REQAANLIAA GADGLRIGMG SGSICITQEV MACGRPQGTA 351 VYNVCEFANQ FGIPCMADGG VQNIGHITKA LALGSSTVMM GGMLAGTTES 401 PGEYFYQDGK RLKAYRGMGS IDAMQKTGTK GNASTSRYFS ESDSVLVAQG 451 VSGAVVDKGS IKKFIPYLYN GLQHSCQDIG YKSLTLLKEN VQSGKVRFEF 501 RTASAQLEGG VHNLHSYEKR LHN*

Amino Acid Sequence (or in FASTA format)

       1  MAAVRDYKTA LEFAKSLPRL DGLSVQELMD SKTRGGLTYN DFLVLPGLVD
      51  FPSSEVSLQT KLTRNITLNT PFVSSPMDTV TESEMAIFMA LLGGIGFIHH
     101  NCTPEDQADM VRRVKNYENG FINNPIVISP TTTVGEAKSM KERFGFSGFP
     151  VTEDGKRNGK LMGIVTSRDI QFVEDNSLLV QDVMTKNPVT GAQGITLSEG
     201  NEILKKIKKG KLLIVDDNGN LVSMLSRTDL MKNQNYPLAS KSATTKQLLC
     251  GAAIGTIDAD KERLRLLVEA GLDVVILDSS QGNSIFQLNM IKWIKETFPD
     301  LEIIAGNVAT REQAANLIAA GADGLRIGMG SGSICITQEV MACGRPQGTA
     351  VYNVCEFANQ FGIPCMADGG VQNIGHITKA LALGSSTVMM GGMLAGTTES
     401  PGEYFYQDGK RLKAYRGMGS IDAMQKTGTK GNASTSRYFS ESDSVLVAQG
     451  VSGAVVDKGS IKKFIPYLYN GLQHSCQDIG YKSLTLLKEN VQSGKVRFEF
     501  RTASAQLEGG VHNLHSYEKR LHN*

external links for Imd3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Imd3p

1)	Escobar-Henriques M and Daignan-Fornier B (2001) Transcriptional regulation of the yeast gmp synthesis pathway by its end products. J Biol Chem 276(2):1523-30
2)	Hyle JW, et al. (2003) Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. J Biol Chem 278(31):28470-8
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41