CRN1/YLR429W Protein Information

Standard Name	Crn1p 1
Systematic Name	Ylr429wp
ORF Classification	Verified
Description	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly (2, 3, 4)
Name Description	CoRoNin 1, 2

Experimental Data
Molecules/cell	2900 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	651
Molecular Weight (Da)	72,553
Isoelectric Point (pI)	5.71

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Crn1p (InterPro)
Physical Interactions	There are 118 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052FB9 \| Q06440 MIPS: YLR429W NCBI: 3121873 \| 51013497 \| 6323460 \| 664873 \| NP_013533.1 GenBank/EMBL/DDBJ: DAA09730.1 \| AY693023 \| U20939

Amino Acid Sequence (or in FASTA format)
1 MSGKFVRASK YRHVFGQAAK KELQYEKLKV TNNAWDSNLL KTNGKFIAVN 51 WNASGGGAFA VIPIEEVGKA PDQVPLFRGH TAQVLDTDFD PFNDHRIASG 101 SDDSKIGIWD IPENYKFHDH VDEDGEPIDI KPVKFLTGHA RKVGHVLYHP 151 VAENVLASSS GDYTVKLWNV ETGKDMITLK HPDMVTSMSF SYDGNYLATV 201 ARDKKLRVWN IREEKIVSEG PAHTGAKNQR VVWLGNSDRL ATTGFSKLSD 251 RQIGIWDAFN IEKGDLGGFY TVDQSSGILM PFYDEGNKIL YLVGKGDGNI 301 RYYEFQNDEL FELSEFQSTE AQRGFAVAPK RMVNVKENEV LKGFKTVVDQ 351 RIEPVSFFVP RRSEEFQEDI YPDAPSNKPA LTAEEWFSGK SVEGPILVSM 401 RSIYDGSAPS FHEAKRPQQP TTQETALEEK KEQPKVEKPI SESEKEVKQE 451 APKSPSPLKS ASSSSTINHV LKEDNSINKL LKKSSDIDQV NNAEDPSRDT 501 SGWEEADDEP APIKIETPVT PTETKKDRTP KVEPSKELKP EPVSIATDRK 551 QEQSLPQEEK SSEKTKSPEQ EKSATPPSSI TAAKTAITAS SKEEPSAART 601 SPKSLGLKKS VEKLSTLVLQ LEDVVDKLTK ANLDKDERLL KLEQKIGELS 651 K*

Amino Acid Sequence (or in FASTA format)

       1  MSGKFVRASK YRHVFGQAAK KELQYEKLKV TNNAWDSNLL KTNGKFIAVN
      51  WNASGGGAFA VIPIEEVGKA PDQVPLFRGH TAQVLDTDFD PFNDHRIASG
     101  SDDSKIGIWD IPENYKFHDH VDEDGEPIDI KPVKFLTGHA RKVGHVLYHP
     151  VAENVLASSS GDYTVKLWNV ETGKDMITLK HPDMVTSMSF SYDGNYLATV
     201  ARDKKLRVWN IREEKIVSEG PAHTGAKNQR VVWLGNSDRL ATTGFSKLSD
     251  RQIGIWDAFN IEKGDLGGFY TVDQSSGILM PFYDEGNKIL YLVGKGDGNI
     301  RYYEFQNDEL FELSEFQSTE AQRGFAVAPK RMVNVKENEV LKGFKTVVDQ
     351  RIEPVSFFVP RRSEEFQEDI YPDAPSNKPA LTAEEWFSGK SVEGPILVSM
     401  RSIYDGSAPS FHEAKRPQQP TTQETALEEK KEQPKVEKPI SESEKEVKQE
     451  APKSPSPLKS ASSSSTINHV LKEDNSINKL LKKSSDIDQV NNAEDPSRDT
     501  SGWEEADDEP APIKIETPVT PTETKKDRTP KVEPSKELKP EPVSIATDRK
     551  QEQSLPQEEK SSEKTKSPEQ EKSATPPSSI TAAKTAITAS SKEEPSAART
     601  SPKSLGLKKS VEKLSTLVLQ LEDVVDKLTK ANLDKDERLL KLEQKIGELS
     651  K*

external links for Crn1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Crn1p

1)	Heil-Chapdelaine RA, et al. (1998) The role of Saccharomyces cerevisiae coronin in the actin and microtubule cytoskeletons. Curr Biol 8(23):1281-4
2)	Goode BL, et al. (1999) Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. J Cell Biol 144(1):83-98
3)	Humphries CL, et al. (2002) Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin. J Cell Biol 159(6):993-1004
4)	Galletta BJ, et al. (2008) Distinct roles for Arp2/3 regulators in actin assembly and endocytosis. PLoS Biol 6(1):e1
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41