TDA5/YLR426W Protein Information

Standard Name	Tda5p 1
Systematic Name	Ylr426wp
ORF Classification	Uncharacterized
Description	Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele (1, 2, 3, 4)
Name Description	Topoisomerase I Damage Affected 1

Experimental Data
Molecules/cell	2130 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	326
Molecular Weight (Da)	36,676
Isoelectric Point (pI)	9.17

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tda5p (InterPro)
Transmembrane Domains	There are 3 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B762 \| Q06417 MIPS: YLR426W NCBI: 6323458 \| 664875 \| 74655012 \| NP_013530.1 GenBank/EMBL/DDBJ: DAA09728.1 \| U20939
External Classifications	EC: 1.-.-.- [Oxidoreductases]

Amino Acid Sequence (or in FASTA format)
1 MNIDCLCRWV VLPLLRYPLL VALVLRWSLS DSISICLTIY TLLINAFLIA 51 NSYIKRSGQV AWKSLREFKN GIVLITGGSK GLGRAIVSQL LQDYSNLTIL 101 NVDICPSSVR NTRVKDLICD LSDDEEVAAL LNLLKRKYKN EIRLIVNNAG 151 VRANFTGFNG MERDNLDKIF KINTFAPLQF IQELAPSRHS TRQCYIVNIA 201 SILGILTPAK VAAYAASKAA LIAFHQSYSF ELQNEGVRNI RTLLVTPGQL 251 NTEMFAGFKP PRQFFAPVID ITTLAAKIVR YCELGQRGQL NEPFYCSFAH 301 LLMCVPYSLQ RIVRSFSRID CCLPDE*

Amino Acid Sequence (or in FASTA format)

       1  MNIDCLCRWV VLPLLRYPLL VALVLRWSLS DSISICLTIY TLLINAFLIA
      51  NSYIKRSGQV AWKSLREFKN GIVLITGGSK GLGRAIVSQL LQDYSNLTIL
     101  NVDICPSSVR NTRVKDLICD LSDDEEVAAL LNLLKRKYKN EIRLIVNNAG
     151  VRANFTGFNG MERDNLDKIF KINTFAPLQF IQELAPSRHS TRQCYIVNIA
     201  SILGILTPAK VAAYAASKAA LIAFHQSYSF ELQNEGVRNI RTLLVTPGQL
     251  NTEMFAGFKP PRQFFAPVID ITTLAAKIVR YCELGQRGQL NEPFYCSFAH
     301  LLMCVPYSLQ RIVRSFSRID CCLPDE*

external links for Tda5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tda5p

1)	Reid RJ, et al. (2011) Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res 21(3):477-86
2)	Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
3)	Lee W, et al. (2005) Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. PLoS Genet 1(2):e24
4)	Reinders J, et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41