TUS1/YLR425W Protein Information Help

Standard Name Tus1p 1
Systematic Name Ylr425wp
Alias Sop10p
ORF Classification Verified
Description Guanine nucleotide exchange factor (GEF) that modulate Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate (1, 2, 3, 4)
Name Description TOR Unique function Suppressor 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,307
Molecular Weight (Da) 149,111
Isoelectric Point (pI) 6.83

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tus1p (InterPro)
Physical Interactions There are 17 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053273 | Q06412
MIPS: YLR425W
NCBI: 398366223 | 664876 | 74644962 | NP_013529.3 | NM_001182313.3
GenBank/EMBL/DDBJ: AAB67506.1 | DAA09727.1 | U20939
Amino Acid Sequence (or in FASTA format)
       1  MYRYNRSSPF ERTPEKRVSR QESQRKSIEL PKLPPLNTRN SFLDDSDNGT
      51  DNISIGWTPI SDTQQFQSPV PQAFTFTSKH SARGNGTSSS ESTPKSTKYV
     101  KERRPPPPPP LLYSTESIRI DSPMVSPSSQ SRERSPNKLS FIGNSEERHH
     151  MEYISNHSRI LKSPFANGFS PNSPKSPRDS SKQQAHFSDE SDLRCHEREK
     201  ALPPIPFTTT LLLSPFDDED SEFFTKPPPP LSTSRNVSGN SRVSEALESV
     251  YSDSDYTFNN SNARQSSFNS LLGAKPLELA PSITAPTQPF SIQSIDEHKL
     301  YQCDNVYKLS AIYEWILKVY FEWFNECVFT KIDLFQIVQL LLEFQMPTNF
     351  DQDTIDSNVD NIMASFISQK AVRFDIINDE EVAVVVGGLD ITGVFTELLP
     401  CYSFIDNTYG STNSLICYSN VCTHGQSSGF RKEIKLSEII NKSVGLWTEY
     451  WHLTPDDLAE INPREVQRQS FIFDLIILEE RSLNMATAAV EIYGKRFDKS
     501  LLPDEPEFKA LAFDIFEPLI QLHTEFLLTP IFWKLKTRGK FIDGVGKIYS
     551  KWCGEAKNIY LNYAKAMATV HEIIMWEKKN KTKFVTWLKE IDNSVEITRS
     601  KMYHDVIFFG GFFKSLQNMP VTLRSILKNT DPSMEDYEYL KIVIKEVEKL
     651  NFEVNQVHGL AIDHRKLVRF SKQLVLSTNS SNATSYVNVG GSTNANDDDA
     701  IQDKLALGLT YPERKLVLSG TVYKKRDLWL DPTPVYIALL DNCLLITEEI
     751  SKGETQKYKL IERPIPIDYL SLEKRKIPGT SKQPLRNYSQ KEHKSPMHNF
     801  STPINSMRPL LKSSGNHMST AYGDRKTSNT EISNANPNTD EFSFKIRNTA
     851  TGESFKFFTE SAEVLNQWID AIMESFKRNA ENHDLNAFEF TVLSSEFAYF
     901  DKDAPVNLPV APEGSEIDVA LKAYAQKANK DSCSWSKTTR ILCCEDVKFE
     951  GRIYLFVATT DGIYVKYRDD YGSGFVKILE LNDVKRMEAN VKLGLLFVLD
    1001  NRKLCYFNIS TVVSRYLAQG NTLDENCIVG TVIRDKVRFF KIADDFGNSK
    1051  HLFFERKGKI VILTPEFDQL TNQVKYFKFY KEYKLPSSSN NILNNEIEDI
    1101  AIFRKSFAVC TKKTVILYQD SFEDNGIVLP SFLNDKDMMA HLRHPHLNSL
    1151  PFKSATDSKK RPSIESLTEE AKKDIATCKA IPVNFFQISQ SSFFALVYDE
    1201  AVVKINCYGE MSDWRKDILL LDFCCTGASF HGNHLILVGD NLIQIYDLKN
    1251  VEQNLGELVP VQIIKGKKIK LASSERREKT ILVLSHPNIL NRQLLVACNP
    1301  VAMADHQ*                                              

external links for Tus1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) CYC2008 (complexes) MIPS YeastGFP
YGOB Complexome Pfam domains
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Tus1p
1) Schmelzle T, et al.  (2002) Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast. Mol Cell Biol 22(5):1329-39
2) Helliwell SB, et al.  (1998) TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae. Genetics 148(1):99-112
3) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
4) Krause SA, et al.  (2012) Functional specialisation of yeast Rho1 GTP exchange factors. J Cell Sci 125(Pt 11):2721-31