ATG17/YLR423C Protein Information

Standard Name	Atg17p 1
Systematic Name	Ylr423cp
Alias	Apg17p 2
ORF Classification	Verified
Description	Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells (3, 4, 5, 6, 7)
Name Description	AuTophaGy related 1

Experimental Data
Molecules/cell	358 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	417
Molecular Weight (Da)	48,656
Isoelectric Point (pI)	4.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atg17p (InterPro)
Physical Interactions	There are 177 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C7E \| Q06410 MIPS: YLR423C NCBI: 398366201 \| 61211713 \| 664879 \| NP_013527.3 GenBank/EMBL/DDBJ: DAA09725.1 \| U20939

Amino Acid Sequence (or in FASTA format)
1 MNEADVTKFV NNARKTLTDA QLLCSSANLR IVDIKKKLSS WQLSISKLNF 51 LIVGLRQQGK FLYTILKEGI GTKLIQKQWN QAVLVVLVDE MKYWQYEITS 101 KVQRLDGIVN ELSISEKDDT DPSKLGDYIS RDNVNLLNDK LKEVPVIERQ 151 IENIKLQYEN MVRKVNKELI DTKLTDVTQK FQSKFGIDNL METNVAEQFS 201 RELTDLEKDL AEIMNSLTQH FDKTLLLQDK KIDNDEREEL FKVVQGDDKE 251 LYNIFKTLHE VIDDVDKTIL NLGQFLQAKI KEKTELHSEV SEIINDFNRN 301 LEYLLIFKDI SNLIDSFKNS CTQDIQTTKE LCEFYDNFEE SYGNLVLEAK 351 RRKDVANRMK TILKDCEKQL QNLDAQDQEE RQNFIAENGT YLPETIWPGK 401 IDDFSSLYTL NYNVKNP*

Amino Acid Sequence (or in FASTA format)

       1  MNEADVTKFV NNARKTLTDA QLLCSSANLR IVDIKKKLSS WQLSISKLNF
      51  LIVGLRQQGK FLYTILKEGI GTKLIQKQWN QAVLVVLVDE MKYWQYEITS
     101  KVQRLDGIVN ELSISEKDDT DPSKLGDYIS RDNVNLLNDK LKEVPVIERQ
     151  IENIKLQYEN MVRKVNKELI DTKLTDVTQK FQSKFGIDNL METNVAEQFS
     201  RELTDLEKDL AEIMNSLTQH FDKTLLLQDK KIDNDEREEL FKVVQGDDKE
     251  LYNIFKTLHE VIDDVDKTIL NLGQFLQAKI KEKTELHSEV SEIINDFNRN
     301  LEYLLIFKDI SNLIDSFKNS CTQDIQTTKE LCEFYDNFEE SYGNLVLEAK
     351  RRKDVANRMK TILKDCEKQL QNLDAQDQEE RQNFIAENGT YLPETIWPGK
     401  IDDFSSLYTL NYNVKNP*

external links for Atg17p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Atg17p

1)	Klionsky DJ, et al. (2003) A unified nomenclature for yeast autophagy-related genes. Dev Cell 5(4):539-45
2)	Kamada Y, et al. (2000) Tor-mediated induction of autophagy via an Apg1 protein kinase complex. J Cell Biol 150(6):1507-13
3)	Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74
4)	Kabeya Y, et al. (2005) Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy. Mol Biol Cell 16(5):2544-53
5)	Cheong H, et al. (2005) Atg17 regulates the magnitude of the autophagic response. Mol Biol Cell 16(7):3438-53
6)	Suzuki K, et al. (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes Cells 12(2):209-18
7)	Morselli E, et al. (2011) p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200. Cell Cycle 10(16):2763-9
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41