CDC73/YLR418C Protein Information Help

Standard Name Cdc73p 1
Systematic Name Ylr418cp
ORF Classification Verified
Description Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress (2, 3, 4, 5, 6, 7, 8, 9)
Name Description Cell Division Cycle 1
Experimental Data
Molecules/cell 538 10
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 393
Molecular Weight (Da) 44,456
Isoelectric Point (pI) 8.01

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cdc73p (InterPro)
Physical Interactions There are 162 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053036 | Q06697
MIPS: YLR418C
NCBI: 375332591 | 401871500 | 401871501 | 6323450 | 632679 | 74644972 | NP_013522.1 | NM_001182306.1
GenBank/EMBL/DDBJ: DAA09720.1 | U20162
Amino Acid Sequence (or in FASTA format)
 
       1  MANSLDRLRE HLKNGDKLVL KNNEGQSTDD ITKATMVETL SSDGSTQDSF
      51  PLNEETEIEI DGSLVQLRII VHCWMNKDSS AADYLADCQN KQLTNVSFLQ
     101  RTDLINWLSG NTESSQYLKA PGQKGETSDK VDIENKTLAG ELSTVKSTTS
     151  ASLENDSEVS DPVVVETMKH ERILVDHNSA LRGAKPINFG YLIKDAELKL
     201  VQSIKGSLRG SKLPPGHKGA HGRISKTNGS SGGPRKDPII LIPSAASSIL
     251  TVANIKQFLL ESKYVNPRNL PSVPNGLVNI EKNFERISRP IRFIIVDNTR
     301  MFTKPEYWDR VVAIFTTGHT WQFNNYQWNS PQELFQRCKG YYFHFAGDSV
     351  PQHVQQWNVE KVELDKNKRF KDVEVVRYFW HSLEKELISR GYR*

external links for Cdc73p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Cdc73p
1) Reed SI, et al.  (1988) Isolation and characterization of two genes encoding yeast mating pheromone signaling elements: CDC72 and CDC73. Cold Spring Harb Symp Quant Biol 53 Pt 2:621-7
2) Chang M, et al.  (1999) A complex containing RNA polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p plays a role in protein kinase C signaling. Mol Cell Biol 19(2):1056-67
3) Shi X, et al.  (1997) Cdc73p and Paf1p are found in a novel RNA polymerase II-containing complex distinct from the Srbp-containing holoenzyme. Mol Cell Biol 17(3):1160-9
4) Mueller CL and Jaehning JA  (2002) Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex. Mol Cell Biol 22(7):1971-80
5) Krogan NJ, et al.  (2003) The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell 11(3):721-9
6) Askree SH, et al.  (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
7) Zhang Y, et al.  (2009) The Paf1 complex is required for efficient transcription elongation by RNA polymerase I. Proc Natl Acad Sci U S A 106(7):2153-8
8) Tous C, et al.  (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64
9) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
10) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41