UTP21/YLR409C Protein Information Help

Standard Name Utp21p 1
Systematic Name Ylr409cp
ORF Classification Verified
Description Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma (2, 3, 4, 5, 6)
Name Description U Three Protein 7
Experimental Data
Molecules/cell 2020 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 939
Molecular Weight (Da) 104,790
Isoelectric Point (pI) 7.8

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Utp21p (InterPro)
Physical Interactions There are 112 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053014 | Q06078
MIPS: YLR409C
NCBI: 15214400 | 398366151 | 625119 | NP_013513.3
GenBank/EMBL/DDBJ: DAA09709.1 | U19729
Amino Acid Sequence (or in FASTA format)
 
       1  MSIDLKKRKV EEDVRSRGKN SKIFSPFRII GNVSNGVPFA TGTLGSTFYI
      51  VTCVGKTFQI YDANTLHLLF VSEKETPSSI VALSAHFHYV YAAYENKVGI
     101  YKRGIEEHLL ELETDANVEH LCIFGDYLCA STDDNSIFIY KKSDPQDKYP
     151  SEFYTKLTVT EIQGGEIVSL QHLATYLNKL TVVTKSNVLL FNVRTGKLVF
     201  TSNEFPDQIT TAEPAPVLDI IALGTVTGEV IMFNMRKGKR IRTIKIPQSR
     251  ISSLSFRTDG SSHLSVGTSS GDLIFYDLDR RSRIHVLKNI HRESYGGVTQ
     301  ATFLNGQPII VTSGGDNSLK EYVFDPSLSQ GSGDVVVQPP RYLRSRGGHS
     351  QPPSYIAFAD SQSHFMLSAS KDRSLWSFSL RKDAQSQEMS QRLHKKQDGG
     401  RVGGSTIKSK FPEIVALAIE NARIGEWENI ITAHKDEKFA RTWDMRNKRV
     451  GRWTFDTTDD GFVKSVAMSQ CGNFGFIGSS NGSITIYNMQ SGILRKKYKL
     501  HKRAVTGISL DGMNRKMVSC GLDGIVGFYD FNKSTLLGKL KLDAPITAMV
     551  YHRSSDLFAL ALDDLSIVVI DAVTQRVVRQ LWGHSNRITA FDFSPEGRWI
     601  VSASLDSTIR TWDLPTGGCI DGIIVDNVAT NVKFSPNGDL LATTHVTGNG
     651  ICIWTNRAQF KTVSTRTIDE SEFARMALPS TSVRGNDSML SGALESNGGE
     701  DLNDIDFNTY TSLEQIDKEL LTLSIGPRSK MNTLLHLDVI RKRSKPKEAP
     751  KKSEKLPFFL QLSGEKVGDE ASVREGIAHE TPEEIHRRDQ EAQKKLDAEE
     801  QMNKFKVTGR LGFESHFTKQ LREGSQSKDY SSLLATLINF SPAAVDLEIR
     851  SLNSFEPFDE IVWFIDALTQ GLKSNKNFEL YETFMSLLFK AHGDVIHANN
     901  KNQDIASALQ NWEDVHKKED RLDDLVKFCM GVAAFVTTA*

external links for Utp21p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Utp21p
1) Samanta MP and Liang S  (2003) Predicting protein functions from redundancies in large-scale protein interaction networks. Proc Natl Acad Sci U S A 100(22):12579-83
2) Bernstein KA, et al.  (2004) The small-subunit processome is a ribosome assembly intermediate. Eukaryot Cell 3(6):1619-26
3) Flom G, et al.  (2005) Novel interaction of the Hsp90 chaperone machine with Ssl2, an essential DNA helicase in Saccharomyces cerevisiae. Curr Genet 47(6):368-80
4) Grandi P, et al.  (2002) 90S pre-ribosomes include the 35S pre-rRNA, the U3 snoRNP, and 40S subunit processing factors but predominantly lack 60S synthesis factors. Mol Cell 10(1):105-15
5) Perez-Fernandez J, et al.  (2007) The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism. Mol Cell Biol 27(15):5414-29
6) Skarie JM and Link BA  (2008) The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. Hum Mol Genet 17(16):2474-85
7) Dragon F, et al.  (2002) A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis. Nature 417(6892):967-70
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41