DUS4/YLR405W Protein Information

Standard Name	Dus4p 1
Systematic Name	Ylr405wp
ORF Classification	Verified
Description	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p (2)
Name Description	DihydroUridine Synthase 1, 2

Experimental Data
Molecules/cell	3390 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	367
Molecular Weight (Da)	41,696
Isoelectric Point (pI)	7.8

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Dus4p (InterPro)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B78F \| Q06063 MIPS: YLR405W NCBI: 2833204 \| 45271062 \| 625099 \| 6323437 \| NP_013509.1 GenBank/EMBL/DDBJ: DAA09704.1 \| AY558586 \| U19729
External Classifications	EC: 1.-.-.- [Oxidoreductases] EC: 1.3.1.90 [tRNA-dihydrouridine(20a/20b) synthase (NAD(P)(+))]

Amino Acid Sequence (or in FASTA format)
1 MHTMHIPSGD VLIPKPKLIT EETDPLHIIK TRQKTHGRPV TIAGPMVRYS 51 KLPFRQLCRE YNVDIVYSPM ILAREYVRNE HARISDLSTN NEDTPLIVQV 101 GVNNVADLLK FVEMVAPYCD GIGINCGCPI KEQIREGIGC ALIYNSDLLC 151 SMVHAVKDKY GDKLRIETKI RIHEALDETV ELCRKLCDAG VDWITIHGRT 201 RRTRSSQPAN LDAIKYIIEN ISDKNVPVIA NGDCFKLSDL ERITKYTGAH 251 GVMAVRGLLS NPALFAGYTT CPWGCIEKFC YWALEFGGLP FQLAQHHLYC 301 MLENMELKKS LLKKMMNLKN YISLIDWFNK TFEFKRYGED GFGMGVEIPY 351 KANSCVQRSA SVVERQE*

Amino Acid Sequence (or in FASTA format)

       1  MHTMHIPSGD VLIPKPKLIT EETDPLHIIK TRQKTHGRPV TIAGPMVRYS
      51  KLPFRQLCRE YNVDIVYSPM ILAREYVRNE HARISDLSTN NEDTPLIVQV
     101  GVNNVADLLK FVEMVAPYCD GIGINCGCPI KEQIREGIGC ALIYNSDLLC
     151  SMVHAVKDKY GDKLRIETKI RIHEALDETV ELCRKLCDAG VDWITIHGRT
     201  RRTRSSQPAN LDAIKYIIEN ISDKNVPVIA NGDCFKLSDL ERITKYTGAH
     251  GVMAVRGLLS NPALFAGYTT CPWGCIEKFC YWALEFGGLP FQLAQHHLYC
     301  MLENMELKKS LLKKMMNLKN YISLIDWFNK TFEFKRYGED GFGMGVEIPY
     351  KANSCVQRSA SVVERQE*

external links for Dus4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Dus4p

1)	Xing F, et al. (2004) The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J Biol Chem 279(17):17850-60
2)	Xing F, et al. (2002) A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA 8(3):370-81
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41