VID22/YLR373C Protein Information Help

Standard Name Vid22p 1
Systematic Name Ylr373cp
ORF Classification Verified
Description Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles; VID22 has a paralog, ENV11, that arose from the whole genome duplication (1, 2, 3)
Name Description Vacuolar Import and Degradation 1
Experimental Data
Molecules/cell 2950 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 901
Molecular Weight (Da) 102,498
Isoelectric Point (pI) 4.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vid22p (InterPro)
Physical Interactions There are 14 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000069855 | Q05934
MIPS: YLR373C
NCBI: 609420 | 6323405 | 74644924 | NP_013477.1
GenBank/EMBL/DDBJ: DAA09676.1 | U19103
Amino Acid Sequence (or in FASTA format)
 
       1  MRAMDTQVQS AERGLVLPPM NSTVSSATAA TTATNTDTDT DGDRDEERES
      51  LAEDGSEWVP AYMLTRDRSR YLGHFLGVDK MLEAVKCKYC GVIIRRQGNS
     101  ISMAEASQTH LWSTHKIDPN ANYYSGWTGV EAGSTFMVRP PLKNHQGGSA
     151  TTNSIANLLE IDEDFLKRTR EKEMALPLVQ SLAIIIASEN LPLSFVDNTA
     201  VRLLINQNAN SLSFIDHDLI LNAIRSIAYN LDRIIQRTAL RNNSDLSLII
     251  DKNYLLMDPT DRSNQLSNRL KNQLFEMQKI NFFSLSHSVW NNTISILSIQ
     301  YYDDFHSQVK TLPLIIQNLH EYNNDPKLSI PAQLLKISQE LPGLQNTVIS
     351  ITLPRSQIVD LLNVMDSQPF FPNTYTNAKN YYHNCIISII NSAILPLFGT
     401  PKSADITHPR QSSFSKEPLT LLDSLIDLSN IDISNSIFSR INSFLDDLQS
     451  NSWQLDKFRS LCEKFGFEFV CSKFDLSRYS TATVSLQTFL NLRPIIEEYQ
     501  SSIQIEKFNE IDFQIIDYLL ITLNSINRIL KFFTSSKSLN FTYVLFAIMS
     551  IEKHLLSTLG SLQFQRLIAP FETFLSKIQE FKTILFSDDM NLLAMFLCPA
     601  ILFEREVLEY SFHTISLSEI VDKLSTSIFS LLKRFLNLHT IGNVNNSHNT
     651  SNHSNMNIHT DNQTNNINNR SGNNSDNNDN EHDNDNDNHS NSNTPASRID
     701  IDPTGGENSV LPEQQPQNSN NNLSFGSLSD THHLSDSTIS KEIDSIFLQI
     751  IQEDLYDYLS TVNSIVPISY RSYCEQSNFI RDSGRFKKRI ITEDSIIGEL
     801  EQPMNFIEEL LDIHVPVCNA FWSQYLDNDA GPIIRILFKI MQCQSSSSIR
     851  GEYSFLNDFI PRVHPDLTQE IIKIKLFNDQ FVASKVDYDL DTLQTASQYL
     901  P*

external links for Vid22p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Vid22p
1) Brown CR, et al.  (2002) Vid22p, a novel plasma membrane protein, is required for the fructose-1,6-bisphosphatase degradation pathway. J Cell Sci 115(Pt 3):655-66
2) Brown CR, et al.  (2001) Cyclophilin A mediates Vid22p function in the import of fructose-1,6-bisphosphatase into Vid vesicles. J Biol Chem 276(51):48017-26
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41