SUR4/YLR372W Protein Information

Standard Name	Sur4p
Systematic Name	Ylr372wp
Alias	Elo3p , Sre1p , Vbm1p , Apa1p
ORF Classification	Verified
Description	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis (1, 2)
Name Description	SUppressor of Rvs161 and rvs167 mutations 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	345
Molecular Weight (Da)	39,465
Isoelectric Point (pI)	10.13

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sur4p (InterPro)
Transmembrane Domains	There are 6 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 92 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004C685 \| P40319 MIPS: YLR372W NCBI: 3378048 \| 398366027 \| 453568 \| 467698 \| 558642 \| 609406 \| 730851 \| NP_013476.3 GenBank/EMBL/DDBJ: DAA09675.1 \| AF011409 \| L28723 \| U19103 \| X78326 \| X82033

Amino Acid Sequence (or in FASTA format)
1 MNTTTSTVIA AVADQFQSLN SSSSCFLKVH VPSIENPFGI ELWPIFSKVF 51 EYFSGYPAEQ FEFIHNKTFL ANGYHAVSII IVYYIIIFGG QAILRALNAS 101 PLKFKLLFEI HNLFLTSISL VLWLLMLEQL VPMVYHNGLF WSICSKEAFA 151 PKLVTLYYLN YLTKFVELID TVFLVLRRKK LLFLHTYHHG ATALLCYTQL 201 IGRTSVEWVV ILLNLGVHVI MYWYYFLSSC GIRVWWKQWV TRFQIIQFLI 251 DLVFVYFATY TFYAHKYLDG ILPNKGTCYG TQAAAAYGYL ILTSYLLLFI 301 SFYIQSYKKG GKKTVKKESE VSGSVASGSS TGVKTSNTKV SSRKA*

Amino Acid Sequence (or in FASTA format)

       1  MNTTTSTVIA AVADQFQSLN SSSSCFLKVH VPSIENPFGI ELWPIFSKVF
      51  EYFSGYPAEQ FEFIHNKTFL ANGYHAVSII IVYYIIIFGG QAILRALNAS
     101  PLKFKLLFEI HNLFLTSISL VLWLLMLEQL VPMVYHNGLF WSICSKEAFA
     151  PKLVTLYYLN YLTKFVELID TVFLVLRRKK LLFLHTYHHG ATALLCYTQL
     201  IGRTSVEWVV ILLNLGVHVI MYWYYFLSSC GIRVWWKQWV TRFQIIQFLI
     251  DLVFVYFATY TFYAHKYLDG ILPNKGTCYG TQAAAAYGYL ILTSYLLLFI
     301  SFYIQSYKKG GKKTVKKESE VSGSVASGSS TGVKTSNTKV SSRKA*

external links for Sur4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sur4p

1)	Oh CS, et al. (1997) ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. J Biol Chem 272(28):17376-84
2)	Kobayashi SD and Nagiec MM (2003) Ceramide/long-chain base phosphate rheostat in Saccharomyces cerevisiae: regulation of ceramide synthesis by Elo3p and Cka2p. Eukaryot Cell 2(2):284-94
3)	Desfarges L, et al. (1993) Yeast mutants affected in viability upon starvation have a modified phospholipid composition. Yeast 9(3):267-77