SSQ1/YLR369W Protein Information Help

Standard Name Ssq1p 1
Systematic Name Ylr369wp
Alias Ssc2p 2 , Ssh1p 3
ORF Classification Verified
Description Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia (2, 4)
Name Description Stress-Seventy subfamily Q
Experimental Data
Molecules/cell 5550 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 657
Molecular Weight (Da) 72,364
Isoelectric Point (pI) 6.3

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ssq1p (InterPro)
Physical Interactions There are 15 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006B324 | Q05931
MIPS: YLR369W
NCBI: 609408 | 6323401 | 74644923 | NP_013473.1
GenBank/EMBL/DDBJ: DAA09672.1 | U19103
Amino Acid Sequence (or in FASTA format)
 
       1  MLKSGRLNFL KLNINSRLLY STNPQLTKKV IGIDLGTTNS AVAYIRDSND
      51  KKSATIIEND EGQRTTPSIV AFDVKSSPQN KDQMKTLVGM AAKRQNAINS
     101  ENTFFATKRL IGRAFNDKEV QRDMAVMPYK IVKCESNGQA YLSTSNGLIQ
     151  SPSQIASILL KYLKQTSEEY LGEKVNLAVI TVPAYFNDSQ RQATKDAGKL
     201  AGLNVLRVIN EPTAAALSFG IDDKRNNGLI AVYDLGGGTF DISILDIEDG
     251  VFEVRATNGD THLGGEDFDN VIVNYIIDTF IHENPEITRE EITKNRETMQ
     301  RLKDVSERAK IDLSHVKKTF IELPFVYKSK HLRVPMTEEE LDNMTLSLIN
     351  RTIPPVKQAL KDADIEPEDI DEVILVGGMT RMPKIRSVVK DLFGKSPNSS
     401  VNPDETVALG AAIQGGILSG EIKNVLLLDV TPLTLGIETF GGAFSPLIPR
     451  NTTVPVKKTE IFSTGVDGQA GVDIKVFQGE RGLVRNNKLI GDLKLTGITP
     501  LPKGIPQIYV TFDIDADGII NVSAAEKSSG KQQSITVIPN SGLSEEEIAK
     551  LIEEANANRA QDNLIRQRLE LISKADIMIS DTENLFKRYE KLISSEKEYS
     601  NIVEDIKALR QAIKNFKANE NDMSIDVNGI KKATDALQGR ALKLFQSATK
     651  NQQNQGK*

external links for Ssq1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Ssq1p
1) Strain J, et al.  (1998) Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly. J Biol Chem 273(47):31138-44
2) Knight SA, et al.  (1998) Mt-Hsp70 homolog, Ssc2p, required for maturation of yeast frataxin and mitochondrial iron homeostasis. J Biol Chem 273(29):18389-93
3) Schilke B, et al.  (1996) The cold sensitivity of a mutant of Saccharomyces cerevisiae lacking a mitochondrial heat shock protein 70 is suppressed by loss of mitochondrial DNA. J Cell Biol 134(3):603-13
4) Muhlenhoff U, et al.  (2003) Components involved in assembly and dislocation of iron-sulfur clusters on the scaffold protein Isu1p. EMBO J 22(18):4815-25
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41