STE11/YLR362W Protein Information Help

Standard Name Ste11p
Systematic Name Ylr362wp
ORF Classification Verified
Description Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5)
Name Description STErile
Experimental Data
Molecules/cell 736 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 717
Molecular Weight (Da) 80,720
Isoelectric Point (pI) 7.19

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ste11p (InterPro)
Physical Interactions There are 138 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001683AC | P23561
MIPS: YLR362W
NCBI: 1711551 | 239938844 | 253722445 | 253722446 | 4554 | 47168508 | 609414 | 6323394 | NP_013466.1
GenBank/EMBL/DDBJ: DAA09666.1 | U19103 | X53431
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
EC: 2.7.11.25 [Mitogen-activated protein kinase kinase kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MEQTQTAEGT DLLIGDEKTN DLPFVQLFLE EIGCTQYLDS FIQCNLVTEE
      51  EIKYLDKDIL IALGVNKIGD RLKILRKSKS FQRDKRIEQV NRLKNLMEKV
     101  SSLSTATLSM NSELIPEKHC VIFILNDGSA KKVNVNGCFN ADSIKKRLIR
     151  RLPHELLATN SNGEVTKMVQ DYDVFVLDYT KNVLHLLYDV ELVTICHAND
     201  RVEKNRLIFV SKDQTPSDKA ISTSKKLYLR TLSALSQVGP SSSNLLAQNK
     251  GISHNNAEGK LRIDNTEKDR IRQIFNQRPP SEFISTNLAG YFPHTDMKRL
     301  QKTMRESFRH SARLSIAQRR PLSAESNNIG DILLKHSNAV DMALLQGLDQ
     351  TRLSSKLDTT KIPKLAHKRP EDNDAISNQL ELLSVESGEE EDHDFFGEDS
     401  DIVSLPTKIA TPKNWLKGAC IGSGSFGSVY LGMNAHTGEL MAVKQVEIKN
     451  NNIGVPTDNN KQANSDENNE QEEQQEKIED VGAVSHPKTN QNIHRKMVDA
     501  LQHEMNLLKE LHHENIVTYY GASQEGGNLN IFLEYVPGGS VSSMLNNYGP
     551  FEESLITNFT RQILIGVAYL HKKNIIHRDI KGANILIDIK GCVKITDFGI
     601  SKKLSPLNKK QNKRASLQGS VFWMSPEVVK QTATTAKADI WSTGCVVIEM
     651  FTGKHPFPDF SQMQAIFKIG TNTTPEIPSW ATSEGKNFLR KAFELDYQYR
     701  PSALELLQHP WLDAHII*

external links for Ste11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome

YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ste11p
1) Rhodes N, et al.  (1990) STE11 is a protein kinase required for cell-type-specific transcription and signal transduction in yeast. Genes Dev 4(11):1862-74
2) O'Rourke SM and Herskowitz I  (1998) The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev 12(18):2874-86
3) Neiman AM and Herskowitz I  (1994) Reconstitution of a yeast protein kinase cascade in vitro: activation of the yeast MEK homologue STE7 by STE11. Proc Natl Acad Sci U S A 91(8):3398-402
4) Grimshaw SJ, et al.  (2004) Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM. J Biol Chem 279(3):2192-201
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41