KAP95/YLR347C Protein Information Help

Standard Name Kap95p 1
Systematic Name Ylr347cp
Alias Rsl1p
ORF Classification Verified
Description Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p (1, 2, 3, 4, 5)
Name Description KAryoPherin 1
Experimental Data
Molecules/cell 51700 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 861
Molecular Weight (Da) 94,775
Isoelectric Point (pI) 4.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kap95p (InterPro)
Physical Interactions There are 267 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F48 | Q06142
MIPS: YLR347C
NCBI: 209870495 | 209870497 | 300193282 | 3183036 | 609394 | 6323379 | 67464126 | 67464642 | 67464644 | NP_013451.1
GenBank/EMBL/DDBJ: DAA09652.1 | U19028
Amino Acid Sequence (or in FASTA format)
 
       1  MSTAEFAQLL ENSILSPDQN IRLTSETQLK KLSNDNFLQF AGLSSQVLID
      51  ENTKLEGRIL AALTLKNELV SKDSVKTQQF AQRWITQVSP EAKNQIKTNA
     101  LTALVSIEPR IANAAAQLIA AIADIELPHG AWPELMKIMV DNTGAEQPEN
     151  VKRASLLALG YMCESADPQS QALVSSSNNI LIAIVQGAQS TETSKAVRLA
     201  ALNALADSLI FIKNNMEREG ERNYLMQVVC EATQAEDIEV QAAAFGCLCK
     251  IMSLYYTFMK PYMEQALYAL TIATMKSPND KVASMTVEFW STICEEEIDI
     301  AYELAQFPQS PLQSYNFALS SIKDVVPNLL NLLTRQNEDP EDDDWNVSMS
     351  AGACLQLFAQ NCGNHILEPV LEFVEQNITA DNWRNREAAV MAFGSIMDGP
     401  DKVQRTYYVH QALPSILNLM NDQSLQVKET TAWCIGRIAD SVAESIDPQQ
     451  HLPGVVQACL IGLQDHPKVA TNCSWTIINL VEQLAEATPS PIYNFYPALV
     501  DGLIGAANRI DNEFNARASA FSALTTMVEY ATDTVAETSA SISTFVMDKL
     551  GQTMSVDENQ LTLEDAQSLQ ELQSNILTVL AAVIRKSPSS VEPVADMLMG
     601  LFFRLLEKKD SAFIEDDVFY AISALAASLG KGFEKYLETF SPYLLKALNQ
     651  VDSPVSITAV GFIADISNSL EEDFRRYSDA MMNVLAQMIS NPNARRELKP
     701  AVLSVFGDIA SNIGADFIPY LNDIMALCVA AQNTKPENGT LEALDYQIKV
     751  LEAVLDAYVG IVAGLHDKPE ALFPYVGTIF QFIAQVAEDP QLYSEDATSR
     801  AAVGLIGDIA AMFPDGSIKQ FYGQDWVIDY IKRTRSGQLF SQATKDTARW
     851  AREQQKRQLS L*

external links for Kap95p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Kap95p
1) Enenkel C, et al.  (1995) Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexes. J Biol Chem 270(28):16499-502
2) Aitchison JD, et al.  (1996) Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteins. Science 274(5287):624-7
3) Gilchrist D and Rexach M  (2003) Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J Biol Chem 278(51):51937-49
4) Mackinnon MA, et al.  (2009) The kap60-kap95 karyopherin complex directly regulates phosphatidylcholine synthesis. J Biol Chem 284(11):7376-84
5) Lonhienne TG, et al.  (2009) Importin-{beta} Is a GDP-to-GTP Exchange Factor of Ran: IMPLICATIONS FOR THE MECHANISM OF NUCLEAR IMPORT. J Biol Chem 284(34):22549-58
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41