RPP0/YLR340W Protein Information

Standard Name	Rpp0p 1
Systematic Name	Ylr340wp
Alias	Rpl10ep 2
ORF Classification	Verified
Description	Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 (3, 4, 5, 6, 7, 8)
Name Description	Ribosomal Protein P0 1
Gene Product	A0 5 , L10E 5 , P0 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	312
Molecular Weight (Da)	33,717
Isoelectric Point (pI)	4.56

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpp0p (InterPro)
Physical Interactions	There are 188 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001683AA \| P05317 MIPS: YLR340W NCBI: 133046 \| 171806 \| 171808 \| 218396 \| 22022642 \| 308153499 \| 315113583 \| 377656240 \| 4371 \| 609387 \| 6323371 \| NP_013444.1 GenBank/EMBL/DDBJ: DAA09644.1 \| D00529 \| M26506 \| M37326 \| U19028 \| X06959 \| X13328

Amino Acid Sequence (or in FASTA format)
1 MGGIREKKAE YFAKLREYLE EYKSLFVVGV DNVSSQQMHE VRKELRGRAV 51 VLMGKNTMVR RAIRGFLSDL PDFEKLLPFV KGNVGFVFTN EPLTEIKNVI 101 VSNRVAAPAR AGAVAPEDIW VRAVNTGMEP GKTSFFQALG VPTKIARGTI 151 EIVSDVKVVD AGNKVGQSEA SLLNLLNISP FTFGLTVVQV YDNGQVFPSS 201 ILDITDEELV SHFVSAVSTI ASISLAIGYP TLPSVGHTLI NNYKDLLAVA 251 IAASYHYPEI EDLVDRIENP EKYAAAAPAA TSAASGDAAP AEEAAAEEEE 301 ESDDDMGFGL FD*

Amino Acid Sequence (or in FASTA format)

       1  MGGIREKKAE YFAKLREYLE EYKSLFVVGV DNVSSQQMHE VRKELRGRAV
      51  VLMGKNTMVR RAIRGFLSDL PDFEKLLPFV KGNVGFVFTN EPLTEIKNVI
     101  VSNRVAAPAR AGAVAPEDIW VRAVNTGMEP GKTSFFQALG VPTKIARGTI
     151  EIVSDVKVVD AGNKVGQSEA SLLNLLNISP FTFGLTVVQV YDNGQVFPSS
     201  ILDITDEELV SHFVSAVSTI ASISLAIGYP TLPSVGHTLI NNYKDLLAVA
     251  IAASYHYPEI EDLVDRIENP EKYAAAAPAA TSAASGDAAP AEEAAAEEEE
     301  ESDDDMGFGL FD*

external links for Rpp0p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rpp0p

1)	Mager WH, et al. (1997) A new nomenclature for the cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Nucleic Acids Res 25(24):4872-5
2)	Cardenas ME, et al. (1999) The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 13(24):3271-9
3)	Rodriguez-Gabriel MA, et al. (1998) Phosphorylation of ribosomal protein P0 is not essential for ribosome function but can affect translation. Biochemistry 37(47):16620-6
4)	Newton CH, et al. (1990) A family of genes encode the multiple forms of the Saccharomyces cerevisiae ribosomal proteins equivalent to the Escherichia coli L12 protein and a single form of the L10-equivalent ribosomal protein. J Bacteriol 172(2):579-88
5)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
6)	Krokowski D, et al. (2005) Acquisition of a stable structure by yeast ribosomal P0 protein requires binding of P1A-P2B complex: in vitro formation of the stalk structure. Biochim Biophys Acta 1724(1-2):59-70
7)	Krokowski D, et al. (2006) Yeast ribosomal P0 protein has two separate binding sites for P1/P2 proteins. Mol Microbiol 60(2):386-400
8)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67