VRP1/YLR337C Protein Information Help

Standard Name Vrp1p 1
Systematic Name Ylr337cp
Alias End5p , Mdp2p , Ylr337wp
ORF Classification Verified
Description Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) (1, 2, 3)
Name Description VeRProlin 1
Gene Product verprolin 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 817
Molecular Weight (Da) 82,593
Isoelectric Point (pI) 10.68

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vrp1p (InterPro)
Physical Interactions There are 74 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053059 | P37370
MIPS: YLR337C
NCBI: 2507155 | 439289 | 609392 | 6323370 | NP_013441.1
GenBank/EMBL/DDBJ: DAA09643.1 | U19028 | Z26645
Amino Acid Sequence (or in FASTA format)
 
       1  MAGAPAPPPP PPPPALGGSA PKPAKSVMQG RDALLGDIRK GMKLKKAETN
      51  DRSAPIVGGG VVSSASGSSG TVSSKGPSMS APPIPGMGAP QLGDILAGGI
     101  PKLKHINNNA STKPSPSASA PPIPGAVPSV AAPPIPNAPL SPAPAVPSIP
     151  SSSAPPIPDI PSSAAPPIPI VPSSPAPPLP LSGASAPKVP QNRPHMPSVR
     201  PAHRSHQRKS SNISLPSVSA PPLPSASLPT HVSNPPQAPP PPPTPTIGLD
     251  SKNIKPTDNA VSPPSSEVPA GGLPFLAEIN ARRSERGAVE GVSSTKIQTE
     301  NHKSPSQPPL PSSAPPIPTS HAPPLPPTAP PPPSLPNVTS APKKATSAPA
     351  PPPPPLPAAM SSASTNSVKA TPVPPTLAPP LPNTTSVPPN KASSMPAPPP
     401  PPPPPPGAFS TSSALSASSI PLAPLPPPPP PSVATSVPSA PPPPPTLTTN
     451  KPSASSKQSK ISSSSSSSAV TPGGPLPFLA EIQKKRDDRF VVGGDTGYTT
     501  QDKQEDVIGS SKDDNVRPSP ISPSINPPKQ SSQNGMSFLD EIESKLHKQT
     551  SSNAFNAPPP HTDAMAPPLP PSAPPPPITS LPTPTASGDD HTNDKSETVL
     601  GMKKAKAPAL PGHVPPPPVP PVLSDDSKNN VPAASLLHDV LPSSNLEKPP
     651  SPPVAAAPPL PTFSAPSLPQ QSVSTSIPSP PPVAPTLSVR TETESISKNP
     701  TKSPPPPPSP STMDTGTSNS PSKNLKQRLF STGGSTLQHK HNTHTNQPDV
     751  DVGRYTIGGS NSIVGAKSGN ERIVIDDSRF KWTNVSQMPK PRPFQNKTKL
     801  YPSGKGSSVP LDLTLFT*

external links for Vrp1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Vrp1p
1) Donnelly SF, et al.  (1993) A proline-rich protein, verprolin, involved in cytoskeletal organization and cellular growth in the yeast Saccharomyces cerevisiae. Mol Microbiol 10(3):585-96
2) Munn AL, et al.  (1995) end5, end6, and end7: mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae. Mol Biol Cell 6(12):1721-42
3) Thanabalu T and Munn AL  (2001) Functions of Vrp1p in cytokinesis and actin patches are distinct and neither requires a WH2/V domain. EMBO J 20(24):6979-89
4) Roumanie O, et al.  (2000) Evidence for the genetic interaction between the actin-binding protein Vrp1 and the RhoGAP Rgd1 mediated through Rho3p and Rho4p in Saccharomyces cerevisiae. Mol Microbiol 36(6):1403-14