SGD1/YLR336C Protein Information Help

Standard Name Sgd1p 1
Systematic Name Ylr336cp
ORF Classification Verified
Description Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia (1, 2, 3, 4)
Name Description Suppressor of Glycerol Defect 1
Experimental Data
Molecules/cell 3060 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 899
Molecular Weight (Da) 102,852
Isoelectric Point (pI) 5.8

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sgd1p (InterPro)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006ADDE | Q06132
MIPS: YLR336C
NCBI: 609391 | 6323368 | 74644935 | NP_013440.1
GenBank/EMBL/DDBJ: DAA09642.1 | U19028
Amino Acid Sequence (or in FASTA format)
 
       1  MQKTDGIRIP GVILDELKTL DYSQDERFSI SEGKKRRRGN GKHLSRKEKR
      51  KMERADKKRK IISTREINSS RLKSAPTSEK RSANAGVKNV GKQANGKNPI
     101  SSDESESNEN WDSDEVLTDE VAEESGEQAM SAEETMKKLE SLKRKAKGIQ
     151  GAENSGEIKG NSYEKKHIRN RDTNENFVSY PLAPSDRSAF ERDEMDMQYY
     201  AKKLGLKGER KAIHAKDEFD AIGGLLEGLE YFENYGKSDE EYGDFATETN
     251  SMRKDDEASE KAFSSDDDLS ASDFEDSDGL SESDNDSVAD SDDNYRREKE
     301  NPYVAPTQSV ESYVPPSLRK KLDDSENNST LSEISKKVNS SLNKLSDSNI
     351  TIIITDLNRL YDSLPRQYVT ESLTKGILNI ISQNQKLLDG FIMNYAALAY
     401  TLSKLRGIEV GAFFIQKTVE AFLHHYEEEM ENILKDQQSK ISSKICINIA
     451  TLLSYCYNFG FVSCRLIYDI IRIFVADPNE FTTELLLRII SISGQLIRGD
     501  DPSALRDIRS ELLKNAKNLK EQSPRLRFLM DTMSDLKNNR LKPSILATDH
     551  HPLKKNLQSI LNSSSSWEPL QVSLEDIKNI DSKGKWWLVG ASWRGNMENA
     601  FEVSINNEND ASKSKKSKIS IEDDLLDDIP DWNIIARQQR MNTDIRRAIF
     651  ISIMSAQDYL DAFSKLEKLS LKNKQVLEIP RIVLHCLLAD SGSNGYNHYY
     701  ALVANKICER YSHLSKSFQF LFWDVIKKFE DKEFDSESDT DEEDDLDDKE
     751  KLLRISNQGR FFGSLLANDI LKLDVFKHVP FMGGLNTEGM LFMEILLFQL
     801  FLTVAKKSEK KLKMDESGNK RIIYSDDYLR DVLTKNVKSE NMLFILKGLK
     851  WFINKKFRYH NFLAGKKGDK AFDRDERRLA WASKAAKSII DKELENIDS*

external links for Sgd1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sgd1p
1) Akhtar N, et al.  (2000) SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase. FEBS Lett 483(2-3):87-92
2) Lin H, et al.  (2002) Phospholipase C interacts with Sgd1p and is required for expression of GPD1 and osmoresistance in Saccharomyces cerevisiae. Mol Genet Genomics 267(3):313-20
3) Simmons HM, et al.  (2005) Identification of NOM1, a nucleolar, eIF4A binding protein encoded within the chromosome 7q36 breakpoint region targeted in cases of pediatric acute myeloid leukemia. Gene 347(1):137-45
4) Li Z, et al.  (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41