NUP2/YLR335W Protein Information Help

Standard Name Nup2p
Systematic Name Ylr335wp
ORF Classification Verified
Description Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization (1, 2, 3, 4, 5)
Name Description NUclear Pore
Experimental Data
Molecules/cell 2960 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 720
Molecular Weight (Da) 77,880
Isoelectric Point (pI) 7.34

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Nup2p (InterPro)
Physical Interactions There are 104 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006A760 | P32499
MIPS: YLR335W
NCBI: 30923217 | 38493063 | 38493064 | 4049 | 609388 | 6323367 | 83754479 | 83754480 | NP_013439.1
GenBank/EMBL/DDBJ: DAA09641.1 | U19028 | X69964
Amino Acid Sequence (or in FASTA format)
 
       1  MAKRVADAQI QRETYDSNES DDDVTPSTKV ASSAVMNRRK IAMPKRRMAF
      51  KPFGSAKSDE TKQASSFSFL NRADGTGEAQ VDNSPTTESN SRLKALNLQF
     101  KAKVDDLVLG KPLADLRPLF TRYELYIKNI LEAPVKSIEN PTQTKGNDAK
     151  PAKVEDVQKS SDSSSEDEVK VEGPKFTIDA KPPISDSVFS FGPKKENRKK
     201  DESDSENDIE IKGPEFKFSG TVSSDVFKLN PSTDKNEKKT ETNAKPFSFS
     251  SATSTTEQTK SKNPLSLTEA TKTNVDNNSK AEASFTFGTK HAADSQNNKP
     301  SFVFGQAAAK PSLEKSSFTF GSTTIEKKND ENSTSNSKPE KSSDSNDSNP
     351  SFSFSIPSKN TPDASKPSFS FGVPNSSKNE TSKPVFSFGA ATPSAKEASQ
     401  EDDNNNVEKP SSKPAFNLIS NAGTEKEKES KKDSKPAFSF GISNGSESKD
     451  SDKPSLPSAV DGENDKKEAT KPAFSFGINT NTTKTADTKA PTFTFGSSAL
     501  ADNKEDVKKP FSFGTSQPNN TPSFSFGKTT ANLPANSSTS PAPSIPSTGF
     551  KFSLPFEQKG SQTTTNDSKE ESTTEATGNE SQDATKVDAT PEESKPINLQ
     601  NGEEDEVALF SQKAKLMTFN AETKSYDSRG VGEMKLLKKK DDPSKVRLLC
     651  RSDGMGNVLL NATVVDSFKY EPLAPGNDNL IKAPTVAADG KLVTYIVKFK
     701  QKEEGRSFTK AIEDAKKEMK *

external links for Nup2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Nup2p
1) Hood JK, et al.  (2000) Nup2p is located on the nuclear side of the nuclear pore complex and coordinates Srp1p/importin-alpha export. J Cell Sci 113 ( Pt 8):1471-80
2) Loeb JD, et al.  (1993) NUP2, a novel yeast nucleoporin, has functional overlap with other proteins of the nuclear pore complex. Mol Biol Cell 4(2):209-22
3) Solsbacher J, et al.  (2000) Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Mol Cell Biol 20(22):8468-79
4) Ishii K, et al.  (2002) Chromatin boundaries in budding yeast: the nuclear pore connection. Cell 109(5):551-62
5) Dilworth DJ, et al.  (2001) Nup2p dynamically associates with the distal regions of the yeast nuclear pore complex. J Cell Biol 153(7):1465-78
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41