NMA1/YLR328W Protein Information

Standard Name	Nma1p 1
Systematic Name	Ylr328wp
ORF Classification	Verified
Description	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; NMA1 has a paralog, NMA2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	Nicotinamide Mononucleotide Adenylyltransferase 1

Experimental Data
Molecules/cell	5130 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	401
Molecular Weight (Da)	45,859
Isoelectric Point (pI)	6.89

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nma1p (InterPro)
Physical Interactions	There are 24 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012FCF7 \| Q06178 MIPS: YLR328W NCBI: 10720127 \| 6323360 \| 662140 \| NP_013432.1 GenBank/EMBL/DDBJ: DAA09636.1 \| U20618
External Classifications	EC: 2.7.7.1 [Nicotinamide-nucleotide adenylyltransferase] EC: 2.7.7.18 [Nicotinate-nucleotide adenylyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MDPTRAPDFK PPSADEELIP PPDPESKIPK SIPIIPYVLA DANSSIDAPF 51 NIKRKKKHPK HHHHHHHSRK EGNDKKHQHI PLNQDDFQPL SAEVSSEDDD 101 ADFRSKERYG SDSTTESETR GVQKYQIADL EEVPHGIVRQ ARTLEDYEFP 151 SHRLSKKLLD PNKLPLVIVA CGSFSPITYL HLRMFEMALD AISEQTRFEV 201 IGGYYSPVSD NYQKQGLAPS YHRVRMCELA CERTSSWLMV DAWESLQPSY 251 TRTAKVLDHF NHEINIKRGG VATVTGEKIG VKIMLLAGGD LIESMGEPNV 301 WADADLHHIL GNYGCLIVER TGSDVRSFLL SHDIMYEHRR NILIIKQLIY 351 NDISSTKVRL FIRRAMSVQY LLPNSVIRYI QEHRLYVDQT EPVKQVLGNK 401 E*

Amino Acid Sequence (or in FASTA format)

       1  MDPTRAPDFK PPSADEELIP PPDPESKIPK SIPIIPYVLA DANSSIDAPF
      51  NIKRKKKHPK HHHHHHHSRK EGNDKKHQHI PLNQDDFQPL SAEVSSEDDD
     101  ADFRSKERYG SDSTTESETR GVQKYQIADL EEVPHGIVRQ ARTLEDYEFP
     151  SHRLSKKLLD PNKLPLVIVA CGSFSPITYL HLRMFEMALD AISEQTRFEV
     201  IGGYYSPVSD NYQKQGLAPS YHRVRMCELA CERTSSWLMV DAWESLQPSY
     251  TRTAKVLDHF NHEINIKRGG VATVTGEKIG VKIMLLAGGD LIESMGEPNV
     301  WADADLHHIL GNYGCLIVER TGSDVRSFLL SHDIMYEHRR NILIIKQLIY
     351  NDISSTKVRL FIRRAMSVQY LLPNSVIRYI QEHRLYVDQT EPVKQVLGNK
     401  E*

external links for Nma1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Nma1p

1)	Anderson RM, et al. (2002) Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem 277(21):18881-90
2)	Emanuelli M, et al. (1999) Identification and characterization of YLR328W, the Saccharomyces cerevisiae structural gene encoding NMN adenylyltransferase. Expression and characterization of the recombinant enzyme. FEBS Lett 455(1-2):13-7
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Belenky P, et al. (2007) Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1/Pnp1/Meu1 pathways to NAD+. Cell 129(3):473-84
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41