CWC24/YLR323C Protein Information

Standard Name	Cwc24p 1
Systematic Name	Ylr323cp
ORF Classification	Verified
Description	Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p (1, 2)
Name Description	Complexed With Cef1p 1

Experimental Data
Molecules/cell	996 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	259
Molecular Weight (Da)	29,741
Isoelectric Point (pI)	9.42

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cwc24p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B7A9 \| P53769 MIPS: YLR323C NCBI: 1730589 \| 6323355 \| 662126 \| NP_013427.1 GenBank/EMBL/DDBJ: DAA09631.1 \| U20618

Amino Acid Sequence (or in FASTA format)
1 MFRKRLVNKS SSDEKNQKKR QKINFSEEKL VASDEEKGSS DLMSLAKSGN 51 SRTLQLSHEN EGKLQKKGED LDKYTLTVND DSTKEDLLNF ERKELAEKAK 101 KRRPSDDNEL VLNMSGKNKR LTKQINQPTN IRTTVLMDFQ PDVCKDYKQT 151 GYCGYGDSCK FLHSRDDFKT GWKLNQEWNA DKEDSKAVTL DLEKIPFKCT 201 LCKEDYKSPV VTNCGHYFCG SCFAKDMKKG TKCFICHKET HGSAKVASDL 251 QKMLNKRKS*

Amino Acid Sequence (or in FASTA format)

       1  MFRKRLVNKS SSDEKNQKKR QKINFSEEKL VASDEEKGSS DLMSLAKSGN
      51  SRTLQLSHEN EGKLQKKGED LDKYTLTVND DSTKEDLLNF ERKELAEKAK
     101  KRRPSDDNEL VLNMSGKNKR LTKQINQPTN IRTTVLMDFQ PDVCKDYKQT
     151  GYCGYGDSCK FLHSRDDFKT GWKLNQEWNA DKEDSKAVTL DLEKIPFKCT
     201  LCKEDYKSPV VTNCGHYFCG SCFAKDMKKG TKCFICHKET HGSAKVASDL
     251  QKMLNKRKS*

external links for Cwc24p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cwc24p

1)	Ohi MD, et al. (2002) Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs. Mol Cell Biol 22(7):2011-24
2)	Ohrt T, et al. (2012) Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS. RNA 18(6):1244-56
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41