IMH1/YLR309C Protein Information Help

Standard Name Imh1p 1
Systematic Name Ylr309cp
Alias Sys3p 2
ORF Classification Verified
Description Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi (3, 4, 5)
Name Description shares with Integrins and Myosins significant Homology 1
Experimental Data
Molecules/cell 2350 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 911
Molecular Weight (Da) 105,224
Isoelectric Point (pI) 5.42

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Imh1p (InterPro)
Physical Interactions There are 46 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006A7C9 | Q06704
MIPS: YLR309C
NCBI: 577221 | 6323340 | 74644975 | NP_013412.1
GenBank/EMBL/DDBJ: DAA09619.1 | U17247
Amino Acid Sequence (or in FASTA format)
 
       1  MFKQLSQIGK NLTDELAKGL ADDMSPTPSE QQIEDDKSGL PKEIQAKLRK
      51  FEKYEQKYPL LLSAYKNEKL KSEKLEAVEK ILAENTPISN IDDAVDTLPA
     101  FFQDLNNKNN LLNDEIKRLT KQNSEIPESA SSETLKDKEE EFLKKEQNYK
     151  NDIDDLKKKM EALNIELDTV QKEKNDTVSG LREKIVALEN ILKEEREAKK
     201  QKEEVSISEL KEELAIKNHS LEDSRMKITE LEQNLSSKST IMEEKSSELA
     251  ELNITLKEKE RKLSELEKKM KELPKAISHQ NVGNNNRRKK NRNKGKKNKG
     301  GITTGDISEE ETVDNSINTE EYDKLKENLQ ELQEKYKDCE DWKQKYEDIE
     351  AELKDAKELE NSQLEKSAKE LETLNTELID TKKSLKEKNS ELEEVRDMLR
     401  TVGNELVDAK DEIKESSSKQ NEEVKTVKLE LDDLRHKNAT MIEAYEAKNT
     451  ELRSKIELLS KKVEHLKNLC TEKEKEQTTS QNKVAKLNEE ISQLTYEKSN
     501  ITKELTSLRT SYKQKEKTVS YLEEQVKQFS EQKDVAEKST EQLRKDHAKI
     551  SNRLDLLKKE NETLHNDIAK NSNSYEEYLK ENGKLSERLN ILQEKYNTLQ
     601  NVKSNSNEHI DSIKRQCEEL NVKLKESTKK ILSLEDELNE YANIVQDKTR
     651  EANTLRRLVS DSQTDDSSKQ KELENKLAYL TDEKNKLEAE LDLQTSRKAT
     701  ELQEWKHTVT ELKSEIHALK LREEGLKSEV DALKHVNNDI KRKTQATSDD
     751  SDQLEQITSN LKLSLSKADE KNFELQSANE KLLNLNNELN KKFDRLLKNY
     801  RSLSSQLNAL KERQYSDKSG RVSRSGSIGT LANANIDSSP ANNSNPTKLE
     851  KIRSSSSLEL DSEKNEKIAY IKNVLLGFLE HKEQRNQLLP VISMLLQLDS
     901  TDEKRLVMSL K*

external links for Imh1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Imh1p
1) Li B and Warner JR  (1996) Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J Biol Chem 271(28):16813-9
2) Tsukada M and Gallwitz D  (1996) Isolation and characterization of SYS genes from yeast, multicopy suppressors of the functional loss of the transport GTPase Ypt6p. J Cell Sci 109 ( Pt 10)():2471-81
3) Kjer-Nielsen L, et al.  (1999) A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Curr Biol 9(7):385-8
4) Tsukada M, et al.  (1999) Structural and functional analysis of a novel coiled-coil protein involved in Ypt6 GTPase-regulated protein transport in yeast. Mol Biol Cell 10(1):63-75
5) Setty SR, et al.  (2003) Golgi recruitment of GRIP domain proteins by Arf-like GTPase 1 is regulated by Arf-like GTPase 3. Curr Biol 13(5):401-4
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41