YHC1/YLR298C Protein Information

Standard Name	Yhc1p 1
Systematic Name	Ylr298cp
ORF Classification	Verified
Description	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site (1, 2)
Name Description	Yeast Homolog of human U1C 1
Gene Product	U1-C 3 , U1C 1

Experimental Data
Molecules/cell	2140 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	231
Molecular Weight (Da)	27,045
Isoelectric Point (pI)	10.92

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Yhc1p (InterPro)
Physical Interactions	There are 77 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005320A \| Q05900 MIPS: YLR298C NCBI: 3024590 \| 51012973 \| 596051 \| 6323329 \| NP_013401.1 GenBank/EMBL/DDBJ: DAA09608.1 \| AY692761 \| U17243

Amino Acid Sequence (or in FASTA format)
1 MTRYYCEYCH SYLTHDTLSV RKSHLVGKNH LRITADYYRN KARDIINKHN 51 HKRRHIGKRG RKERENSSQN ETLKVTCLSN KEKRHIMHVK KMNQKELAQT 101 SIDTLKLLYD GSPGYSKVFV DANRFDIGDL VKASKLPQRA NEKSAHHSFK 151 QTSRSRDETC ESNPFPRLNN PKKLEPPKIL SQWSNTIPKT SIFYSVDILQ 201 TTIKESKKRM HSDGIRKPSS ANGYKRRRYG N*

Amino Acid Sequence (or in FASTA format)

       1  MTRYYCEYCH SYLTHDTLSV RKSHLVGKNH LRITADYYRN KARDIINKHN
      51  HKRRHIGKRG RKERENSSQN ETLKVTCLSN KEKRHIMHVK KMNQKELAQT
     101  SIDTLKLLYD GSPGYSKVFV DANRFDIGDL VKASKLPQRA NEKSAHHSFK
     151  QTSRSRDETC ESNPFPRLNN PKKLEPPKIL SQWSNTIPKT SIFYSVDILQ
     201  TTIKESKKRM HSDGIRKPSS ANGYKRRRYG N*

external links for Yhc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Yhc1p

1)	Tang J, et al. (1997) Identification and characterization of a yeast homolog of U1 snRNP-specific protein C. EMBO J 16(13):4082-91
2)	Zhang D and Rosbash M (1999) Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Genes Dev 13(5):581-92
3)	Neubauer G, et al. (1997) Identification of the proteins of the yeast U1 small nuclear ribonucleoprotein complex by mass spectrometry. Proc Natl Acad Sci U S A 94(2):385-90
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41